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J Appl Physiol (September 27, 2002). doi:10.1152/japplphysiol.00177.2002
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Articles in PresS, published online ahead of print September 27, 2002
J Appl Physiol, 10.1152/jap.00177.2002
Submitted on March 5, 2002
Accepted on September 20, 2002

The effects of obstructive sleep apnea on circulating ICAM-1, IL-8 and MCP-1

Eijiro Ohga1, Tetsuji Tomita1, Hiroo Wada1, Hiroshi Yamamoto1, Takahide Nagase1*, and Yasuyoshi Ouchi1

1 Department of Geriatric Medicine, University of Tokyo, Faculty of Medicine, Tokyo, Japan

* To whom correspondence should be addressed. E-mail: takahide-tky{at}umin.ac.jp.

Obstructive sleep apnea syndrome (OSAS) is one of the most important risk factors of cardiovascular disorders. In the treatment of OSAS, nasal continuous positive airway pressure (nCPAP) has been widely used and reported to be effective. In the current study, we hypothesized that the hypoxic stress caused by obstructive sleep apnea would increase circulating ICAM-1, IL-8 and MCP-1 in untreated OSAS patients as compared to an age-matched control group. In addition, we hypothesized that nCPAP may decrease OSAS-induced hypoxic stress and mediators. To examine these hypotheses, we measured circulating ICAM-1 and IL-8 before and after nCPAP therapy in OSAS patients. We observed that nCPAP decreased apnea, desaturation, and the circulating ICAM-1 and IL-8 levels in OSAS patients. The circulating levels of ICAM-1, IL-8 and MCP-1 in untreated OSAS patients were significantly greater than those in the controls. These observations suggest that nCPAP therapy could reduce OSAS-induced hypoxia and generation of inflammatory mediators. Treatment of OSAS using nCPAP can be, therefore, potential approach to decrease risk of the progression of OSAS-associated disorders.




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