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1 Department of Infectious Diseases, Rigshospital, Copenhagen, Denmark; The Copenhagen Muscle Research Centre, Rigshospital, Copenhagen, Denmark
2 The Copenhagen Muscle Research Centre, Rigshospital, Copenhagen, Denmark
* To whom correspondence should be addressed. E-mail: bkp{at}rh.dk.
Low muscle glycogen content has been demonstrated to enhance transcription of a number of genes involved in training adaptation. These results made us speculate that training at a low muscle glycogen content would enhance training adaptation. We therefore performed a study in which seven healthy untrained males performed one-knee legged exercise training at a low glycogen (Low) protocol, whereas the other leg was trained at a high glycogen (High) protocol. Both legs were trained equally regarding workload and training amount. Day one: Both legs (Low+High) were trained for 1 hour followed by 2 hours of rest at a fasting state, where after one leg (Low) was trained for 1 more hour. Day 2: Only one leg (High) trained for 1 hour. Days 1 and 2 were repeated for 10 weeks. As an effect of training, the increase in maximal workload was identical for the two legs. However, time till exhaustion at 90% was markedly more increased in the Low leg compared with the High leg. Resting muscle glycogen and the activity of the mitochondrial enzyme hydroxyacyl CoA dehydrogenase (HAD) increased with training, but only significantly so in LOW, whereas citrate synthase (CS) activity increased in both low and high. There was a more pronounced increase in CS activity when Low was compared with High. In conclusion, the present study suggests that training twice every second day may be superior to daily training.
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