Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
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J Appl Physiol (April 26, 2007). doi:10.1152/japplphysiol.00157.2007
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Submitted on February 7, 2007
Accepted on April 20, 2007

The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans

Abigail Louise Mackey1*, Michael Kjaer2, Sune Dandanell Jørgensen2, Kristian Handberg Mikkelsen1, Lars Holm1, Simon Døssing1, Fawzi Kadi3, Satu O A Koskinen1, Charlotte H Jensen4, Henrik D Schrøder5, and Henning Langberg2

1 Institute of Sports Medicine Copenhagen, Copenhagen, Denmark
2 Institute of Sports Medicine Copenhagen, Denmark
3 Department of Physical Education and Health, Örebro University, Örebro , Sweden
4 Department of Immunology and Microbiology, University of Southern Denmark, Denmark
5 Department of Pathology, Odense University Hospital, Denmark

* To whom correspondence should be addressed. E-mail: abigail.mackey{at}gmail.com.

The consumption of nonsteroidal anti-inflammatory drugs (NSAIDs) is widespread among athletes when faced with muscle soreness or injury, but the effects of NSAIDs on satellite cell activity in humans are unknown. In order to investigate this, 14 healthy male endurance athletes (mean VO2peak: 62 ml.kg-1.min-1) volunteered for the study which involved running 36 km. They were divided into two groups, and received either 100 mg indomethacin per day or placebo. Muscle biopsies collected before the run and on days 1, 3, and 8 afterwards were analysed for satellite cells by immunohistochemistry with the aid of neural cell adhesion molecule (NCAM) and fetal antigen-1 (FA1) antibodies. Muscle biopsies were also collected from untrained individuals for comparison. Compared to pre-exercise levels, a 27% increase in the number of NCAM+ cells was observed on day 8 post exercise in the placebo group (P < 0.05), while levels remained similar at all time points in the NSAID group. No change was seen in the proportion of FA1+ cells, although lower levels were found in the muscle of endurance trained athletes when compared to untrained individuals (P < 0.05). These results suggest that ingestion of anti-inflammatory drugs attenuates the exercise-induced increase in satellite cell number, supporting the role of the cyclooxygenase pathway in satellite cell activity.




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