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J Appl Physiol (July 12, 2002). doi:10.1152/japplphysiol.00145.2002
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Articles in PresS, published online ahead of print July 12, 2002
J Appl Physiol, 10.1152/jap.00145.2002
Submitted on February 25, 2002
Accepted on July 5, 2002

Level of physical capacity influences the response of insulin-like growth factor and its binding proteins to prolonged physical training

Lars Rosendal1*, Henning Langberg2, Allan Flyvbjerg3, Jan Frystyk3, Hans Orskov3, and Michael Kjaer2

1 Sports Medicine Research Unit and Copenhagen Muscle Research Centre, Bispebjerg Hospital, Copenhagen, Denmark; National Institute of Occupational Health, Copenhagen, Denmark
2 Sports Medicine Research Unit and Copenhagen Muscle Research Centre, Bispebjerg Hospital, Copenhagen, Denmark
3 Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark

* To whom correspondence should be addressed. E-mail: LRL{at}ami.dk.

The influence of initial training status on the response of circulating IGF and its binding proteins to prolonged physical training was studied in young men. It was hypothesized that highly standardized training would result in more extensive changes in the circulating IGF system in untrained subjects due to lower fitness level. Seven untrained (UT) and 12 well-trained (WT) individuals performed 11 weeks of intense physical training (2-4 h daily). Fasting serum samples were analysed for total and free IGF-I and -II, IGFBP-1 to -4 as well as for IGFBP-3 proteolysis. Eleven weeks of physical training resulted in decreased levels of total IGF-I, free IGF-I, and IGFBP-4 in both UT and WT. In the UT group, IGFBP-2 increased, IGFBP-3 decreased (mean±SD) (4255±410 µg/L (baseline) to 3896±465µg/L (week 4), p<0.05), and IGFBP-3 proteolysis increased (from 28±8% (baseline) to 37±7% (week 4) and 39±12% (week 11), p<0.05), whereas no significant changes were found in the WT group. In conclusion, intense physical training results in a marked influence on the IGF system and its binding proteins with generally more extensive changes seen in the untrained individuals. Also, prolonged physical training resulted in increased IGFBP-3 proteolysis in previously untrained individuals only, indicating that intense physical training affects trained and untrained individuals differently.




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