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J Appl Physiol (February 16, 2006). doi:10.1152/japplphysiol.00143.2006
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Submitted on February 6, 2006
Accepted on February 15, 2006

Plasticity in the nucleus tractus solitarius (NTS) and its influence on lung and airway reflexes

Ann C. Bonham1*, Chao-Yin Chen1, Shin-ichi Sekizawa1, and Jesse P. Joad2

1 Department of Medical Pharmacology and Toxicology, University of California Davis, Davis, CA, USA
2 Department of Pediatrics, University of California Davis, Davis, CA, USA

* To whom correspondence should be addressed. E-mail: ann.bonham{at}ucdmc.ucdavis.edu.

The nucleus tractus solitarius (NTS) is the first CNS site for synaptic contact of the primary afferent fibers from the lungs and airways. The signal processing at these synapses will determine the output of the sensory information from the lungs and airways to all downstream synapses in the reflex pathways. The second-order NTS neurons bring to bear their own intrinsic and synaptic properties to temporally and spatially integrate the sensory information with inputs from local networks, higher brain regions and circulating mediators, to orchestrate a coherent reflex output. There is growing evidence that NTS neurons share the rich repertoire of forms of plasticity demonstrated throughout the CNS. This review focuses on existing evidence for plasticity in the NTS, potential targets for plasticity in the NTS, and the impact of this plasticity on lung and airway reflexes.




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