Journal of Applied Physiology
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J Appl Physiol (September 13, 2002). doi:10.1152/japplphysiol.00134.2002
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Articles in PresS, published online ahead of print September 13, 2002
J Appl Physiol, 10.1152/jap.00134.2002
Submitted on February 21, 2002
Accepted on September 10, 2002

LOCALLY AND SYSTEMICALLY ACTIVE GLUCOCORTICOSTEROIDS MODIFY INTESTINAL ABSORPTION OF SUGARS IN RATS

A. Thiesen1, G. E Wild2, M. Keelan1, M. T Clandinin3, and Alan B Thomson1*

1 Nutrition and Metabolism Research Group, Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
2 Division of Gastroenterology, and Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
3 Department of Food Sciences and Nutrition, University of Alberta, Edmonton, Alberta, Canada

* To whom correspondence should be addressed. E-mail: alan.thomson{at}ualberta.ca.

Glucocorticosteroids enhance digestive and absorptive functions of the intestine of weaning and adult rats. This study was undertaken to assess the influence of treatment of weaning male rats with budesonide, prednisone, or control vehicle (CON) on the in vitro jejunal and ileal uptake of glucose and fructose. BUD and PRED had no effect on the uptake of D-glucose by SGLT1. In contrast, the uptake of D-fructose by GLUT5 was similarly increased with BUD and with PRED. The increases in the uptake of fructose were not due to variations in the weight of the intestinal mucosa, food intake, or in GLUT5 protein or mRNA expression. There were no steroid-associated changes in mRNA expression of c-myc, c-jun, c-fos, of proglucagon, or of selected cytokines. However, the abundance of ileal ODC mRNA was increased with PRED. Giving post- weaning rats four weeks of BUD or PRED in doses equivalent to those used in clinical practice increases fructose but not glucose uptake. This enhanced uptake of fructose was likely regulated by post-translational processes.




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