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J Appl Physiol (September 24, 2004). doi:10.1152/japplphysiol.00130.2004
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Submitted on February 4, 2004
Accepted on September 21, 2004

Increase in interstitial interleukin-6 of human skeletal muscle with repetitive low-force exercise

Lars Rosendal1*, Karen Sogaard2, Michael Kjaer3, Gisela Sjogaard2, Henning Langberg3, and Jesper Kristiansen2

1 National Institute of Occupational Health, Copenhagen, DK-2100, Denmark; Pain and Occupational Medicine Centre, University Hospital, Linkoping, SE-581 85, Sweden
2 National Institute of Occupational Health, Copenhagen, DK-2100, Denmark
3 Sports Medicine Research Unit and Copenhagen Muscle Research Centre, Bispebjerg Hosptial, Copenhagen, DK-2400, Denmark

* To whom correspondence should be addressed. E-mail: LRL{at}ami.dk.

Interleukin-6 (IL-6), which is released from muscle tissue during intense exercise, possesses important metabolic and probably anti-inflammatory properties. To evaluate the IL-6 response to low-intensity exercise we conducted two studies: I) a control study with insertion of microdialysis catheters in muscle and determination of interstitial muscle IL-6 response over two hours of rest and II) an exercise study to investigate the IL-6 response to 20 min repetitive low-force exercise. In both studies a microdialysis catheter (cut-off 3000 kDa) was inserted into the upper trapezius muscle of 6 male subjects and the catheters were perfused with ringer-acetat at 5 µl min-1. Venous plasma samples were taken in the exercise study. The insertion of microdialysis catheters into muscle resulted in an increase in IL-6 from 8 ± 0 pg ml-1 to 359 ± 171 and 484 ± 202 pg ml-1 after 65 and 110 min, respectively (P<0.001). Similarly, in the exercise study, IL-6 increased to 289 ± 128 pg ml-1 after 55 min rest (P<0.001). During the subsequent repetitive low-force exercise, muscle IL-6 further increased to 1246 ± 461 pg ml-1, and reached 2132 ± 477 pg ml-1 after 30 min recovery (all P<0.001). In contrast to this, plasma IL-6 did not significantly change in response to exercise. We conclude that upper extremity, low-intensity exercise results in a substantial increase in IL-6 in the interstitium of the stabilizing trapezius muscle, whereas no change is seen for plasma IL-6.




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