Journal of Applied Physiology
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J Appl Physiol (May 1, 2008). doi:10.1152/japplphysiol.00120.2008
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Submitted on February 1, 2008
Accepted on April 29, 2008

Focal CO2 dialysis in raphe obscurus (ROb) does not stimulate ventilation but enhances the response to focal CO2 dialysis in the retrotrapezoid nucleus (RTN)

Mirela Barros Dias1, Aihua Li2, and Eugene E. Nattie3*

1 University of Sao Paulo, Physiology, School of Medicine of Ribeirao Preto, Brazil
2 Dept Physiol Dartmouth Med Sch, Lebanon (USA), Lebanon, New Hampshire, United States
3 Dept Physiol Dartmouth Med Sch, Lebanon (USA), Lebanon, New Hampshire, United States; , United States

* To whom correspondence should be addressed. E-mail: eugene.nattie{at}dartmouth.edu.

Simultaneous inhibition of the RTN and ROb decreased the systemic CO2 response by 51%, an effect greater than inhibition of RTN (-24%) or ROb (0%) alone, suggesting that ROb modulates chemoreception by interaction with the RTN (19). We investigate this interaction further by simultaneous dialysis of artificial cerebrospinal fluid equilibrated with 25% CO2 in two probes located in, or adjacent to, the RTN and ROb in conscious adult male rats. Ventilation is measured in a whole body plethysmograph at 30 degrees C. There are four groups (N=5): 1) probes correctly placed in both RTN and ROb (RTN - ROb); 2) one probe correctly placed in RTN, one incorrectly placed in areas adjacent to ROb (RTN - peri-ROb); 3) one correctly placed in ROb, one probe incorrectly placed in areas adjacent to RTN (peri-RTN - ROb); 4) neither probe correctly placed (peri-RTN-peri-ROb). Focal simultaneous acidification of RTN-ROb significantly increased VE up to 22% compared to baseline, with significant increases in both f and VT. Focal acidification of RTN-peri-ROb increased significantly by up to 15% compared to baseline. Focal acidification of ROb and peri-RTN had no significant effect. The simultaneous acidification of regions just outside the RTN and ROb actually decreased E by up to 11%. These results support a modulatory role for the ROb with respect to central chemoreception at the RTN.




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