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1 Department of Medical Informatics and Engineering, University of Szeged, Szeged, Hungary; Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia
2 Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia
3 Department of Medical Informatics and Engineering, University of Szeged, Szeged, Hungary
* To whom correspondence should be addressed. E-mail: hantos{at}dmi.u-szeged.hu.
A tracking impedance estimation technique was developed to follow the changes in total respiratory impedance (Zrs) during slow TLC maneuvers in 6 anesthetized and mechanically ventilated BALB/c mice. Zrs was measured with the wave tube technique and pseudorandom forced oscillations at 9 frequencies between 4 and 38 Hz during inflation from a transrespiratory pressure (Prs) of 0 to 20 cmH2O and subsequent deflation, each lasting for ~20 s. Zrs was averaged for 0.125 s and fitted by a model featuring airway resistance (Raw) and inertance, and tissue damping and elastance (H). Lower airway conductance (Glaw) was linearly related to volume above FRC (V) between 0 and 75-95% Vmax, with a mean slope of dGlaw/dV=13.6±4.6 cmH2O-1.s-1. The interdependence of Raw and H was characterized by two distinct and closely linear relationships for the low- and high-volume regions, separated at ~40% Vmax. Comparison of Raw with the highest-frequency Rrs revealed a marked volume-dependent contribution of tissue resistance to Rrs, resulting in the overestimation of Raw by 19±8% and 163±40% at FRC and TLC, respectively, whereas the lowest-frequency reactance was proportional to H; these findings indicate that single-frequency resistance values may become inappropriate as surrogates of Raw when tissue impedance is changing.
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