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J Appl Physiol (May 31, 2002). doi:10.1152/japplphysiol.00104.2002
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Articles in PresS, published online ahead of print May 31, 2002
J Appl Physiol, 10.1152/jap.00104.2002
Submitted on February 7, 2002
Accepted on May 9, 2002

Serotonergic modulation of respiratory motor output during tadpole development

Richard Kinkead1*, Olivier Belzile1, and Roumiana Gulemetova1

1 Department of Pediatrics, Laval University, Quebec City, Quebec, Canada

* To whom correspondence should be addressed. E-mail: Richard.Kindead{at}crsfa.ulaval.ca.

To test the hypothesis that 5-HT receptor activation elicits age-dependent changes in respiratory motor output, we compared the effects of 5-HT bath application ([5-HT]: 0.5 to 25 µM) onto in vitro brainstem preparations from pre- and post-metamorphic bullfrog tadpoles. Recording of motor output related to gill and lung ventilation showed that 5-HT elicits a dose-dependent depression of gill burst frequency in both groups. In contrast, the lung burst frequency response was stage-dependent; an increase in lung burst frequency at low 5-HT conc. ([5-HT] <= 0.5 µM) was observed only in the post-metamorphic group. Higher 5-HT concentrations decreased lung burst frequency in all preparations. Gill burst frequency attenuation is mediated (at least in part) by 5-HT1A receptor activation in an age-dependent fashion. We conclude that 5-HT modulation of respiratory motor output 1) changes during tadpole development and 2) is distinct for gill and lung ventilation.




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