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J Appl Physiol (November 14, 2003). doi:10.1152/japplphysiol.00092.2003
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Submitted on January 29, 2003
Accepted on November 6, 2003

Physiological evaluation of a new quantitative SPECT method measuring regional ventilation and perfusion

Johan Petersson1*, Alejandro Sanchez-Crespo2, Malin Rohdin3, Stephanie Montmerle3, Sven Nyren4, Hans Jacobsson5, Stig A Larsson2, Sten G Lindahl1, Dag Linnarsson3, Robb W Glenny6, and Margareta Mure1

1 Department of Anesthesiology and Intensive Care, Karolinska Hospital, SE-171 76 Stockholm, Sweden
2 Section of Nuclear Medicine, Department of Hospital Physics, Karolinska Hospital, SE-171 76 Stockholm, Sweden; Medical Radiation Physics, Department of Oncology-Pathology, Stockholm University and Karolinska Institute, SE-171 77 Stockholm, Sweden
3 Section of Environmental Physiology, Department of Physiology and Pharmacology, Karolinska Institute, SE-171 77 Stockholm, Sweden
4 Department of Radiology, Karolinska Hospital, SE-171 76 Stockholm, Sweden
5 Section of Nuclear Medicine, Department of Hospital Physics, Karolinska Hospital, SE-171 76 Stockholm, Sweden; Department of Radiology, Karolinska Hospital, SE-171 76 Stockholm, Sweden
6 Department of Anesthesiology and Intensive Care, Karolinska Hospital, SE-171 76 Stockholm, Sweden; Departments of Medicine and Physiology and Biophysics, University of Washington, Seattle 98 195, Washington, USA

* To whom correspondence should be addressed. E-mail: johan.petersson{at}ks.se.

We have developed a new quantitative Single Photon Emission Computed Tomography (SPECT) method that uses 113mIn-labelled albumin macroaggregates and Technegas (99mTc) to estimate the distributions of regional ventilation and perfusion for the whole lung. The Multiple Inert Gas Elimination Technique (MIGET) and whole lung respiratory gas exchange were used as physiologic evaluations of the SPECT method. Regional ventilation and perfusion were estimated by SPECT in 9 healthy volunteers during awake spontaneous breathing. Radiotracers were administered sitting upright and SPECT images acquired supine. Whole lung gas exchange of MIGET gases and arterial PO2 and PCO2 gases were predicted from estimates of regional ventilation and perfusion. We found a good agreement between measured and SPECT-predicted exchange of MIGET and respiratory gases. Correlations (r2) between SPECT-predicted and measured inert gas excretions and retentions were 0.99. The method offers a new tool for measuring regional ventilation and perfusion in humans.




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