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Articles in PresS, published online ahead of print August 2, 2002
J Appl Physiol, 10.1152/jap.00091.2002
Submitted on February 4, 2002
Accepted on July 23, 2002
1 Department of Exercise Science, University of Massachusetts, Amherst, Amherst, MA, USA; Radiology Department, University of California, San Francsico, San Francisco, CA, USA
2 Exercise Science Program, Marquette University, Milwaukee, WI, USA; Radiology Department, University of California, San Francsico, San Francisco, CA, USA
3 Radiology Department, University of California, San Francsico, San Francisco, CA, USA
4 Department of Exercise Science, University of Massachusetts, Amherst, Amherst, MA, USA
* To whom correspondence should be addressed. E-mail: janekb{at}excsci.umass.edu.
The purpose of this study was to compare the magnitude and mechanisms of ankle dorsiflexor muscle fatigue in 20 young (33±6 years, mean±SD) and 21 older (75±6 years) healthy men and women of similar physical activity status. Noninvasive measures of central (CNS) and peripheral (neuromuscular junction, sarcolemma) muscle activation, muscle contractile function and intramuscular energy metabolism were made before, during and after incremental isometric exercise. Older subjects fatigued less than young (p<0.01); there was no effect of gender on fatigue (p=0.24). For all subjects combined, fatigue was modestly related to pre-exercise strength (r=0.49, p<0.01). Neither central (central activation ratio) nor peripheral (compound muscle action potential) activation played a significant role in fatigue in any group, and the slowing of force relaxation at fatigue was similar in all groups. During exercise, intramuscular pH fell more in young compared with older subjects (p<0.01), and in men compared with women (p<0.01). There was no age effect on the change in Pi/PCr during exercise (p=0.76), but men had a greater increase in Pi/PCr compared with women (p<0.01). These varied metabolic responses to exercise suggest a greater reliance on non-oxidative sources of ATP in young compared with older subjects, and in men compared with women. In conclusion, the increased fatigue resistance observed with age was associated with a differing metabolic response to exercise compared with young. In contrast, the similar fatigue in men and women was achieved despite their differing metabolic responses. These results suggest that the mechanisms of fatigue vary with age and gender, regardless of whether differences in the magnitude of fatigue are observed.
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