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1 Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
2 Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Hvidovre Hospital, Hvidovre, Denmark; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
* To whom correspondence should be addressed. E-mail: bhanel{at}mobilixnet.dk.
The purpose of the study was to evaluate the effects of maximal exercise on the integrity of the alveolar epithelial membrane using the clearance rate of aerosolised 99m Tc-labeled diethylenetriaminepentaacetic acid (99mDTPA) as an index for the permeability of the lung blood-gas barrier (BGB). Ten elite rowers (age = 24.3 ± 4.6 yr) completed two 20- min pulmonary clearance measurements immediately after and two hours after 6-min all-out rowing (Initial and Late), respectively. All subjects participated in resting control measurements on a separate day. For each 20-min measurement, lung clearance was calculated for 0-7 min and 10-20 min. Furthermore, scintigrams were processed from the Initial and Late measurements of DTPA clearance. Compared to control levels, the pulmonary clearance measurement after rowing was increased from 1.2 ± 0.5 %/min (SD) to 2.4 ± 1.0 %/min at 0-7 min (p<0.01) and from 0.8 ± 0.3 %/min to 1.5 ± 0.4 %/min at 10-20 min (p <0.0005), returning to resting levels within two hours. Six of ten subjects had inhomogeneous ventilation distribution on the lung scintigrams at the Initial measurement. The study demonstrates an acute increased pulmonary clearance after maximal rowing. The ventilation defects identified on the lung scintigrams may represent transient interstitial edema secondary to increased BGB permeability induced by mechanical stress.
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