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J Appl Physiol (April 15, 2002). doi:10.1152/japplphysiol.00081.2002
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Articles in PresS, published online ahead of print April 15, 2002
J Appl Physiol, 10.1152/jap.00081.2002
Submitted on January 31, 2002
Accepted on April 13, 2002

Detection of local lung air content by electrical impedance tomography in comparison with electron beam CT

Inez Frerichs1*, Jose Hinz1, Peter Herrmann2, Gerald Weisser3, Gunter Hahn1, Taras Dudykevych1, Michael Quintel2, and Gerhard Hellige1

1 Department Anaesthesiological Research, University of Goettingen, Goettingen, Germany
2 Institute of Anesthesiology and Operative Intensive Care, University Hospital Mannheim, Mannheim, Germany
3 Institute of Clinical Radiology, University Hospital Mannheim, Mannheim, Germany

* To whom correspondence should be addressed. E-mail: isipink{at}gwdg.de.

The aim of the study was to validate the ability of electrical impedance tomography (EIT) to detect local changes in air content resulting from modified ventilator settings by comparing EIT findings with electron beam CT (EBCT) scans obtained under identical steady state conditions. The experiments were carried out on six anaesthetized supine pigs ventilated with five tidal volumes (VT) at three positive end-expiratory pressure (PEEP) levels. The lung air content changes were determined both by EIT (Goe-MF1 system) and EBCT (Imatron C-150XP scanner) in six regions of interest located in the ventral, middle and dorsal areas of each lung with respect to the reference air content at the lowest VT and PEEP either as a change in local electrical impedance or lung tissue density. An increase in local air content with VT and PEEP was identified by both methods at all regions studied. A good correlation between the changes in lung air content determined by EIT and EBCT was revealed. Mean correlation coefficients in the ventral, middle and dorsal regions were 0.81, 0.87 and 0.93, respectively. The study confirms that EIT is a suitable noninvasive method for detecting regional changes in air content and monitoring local effects of artificial ventilation.




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