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1 Experimental Cardiovascular Biology, Institut de recherches cliniques de Montreal, Montreal, QC, Canada
2 Pathology, University of California at San Francisco, San Francisco, CA, USA
3 Medicine, University of Sherbrooke, Sherbrooke, QC, Canada
* To whom correspondence should be addressed. E-mail: deschec{at}ircm.qc.ca.
To better understand the contributions of various genetic backgrounds to complex quantitative phenotypes, we have measured several quantitative traits of cardiovascular interest [i.e. systolic blood pressure, weight (corrected by body weight) of several cardiac compartments, of adrenals and of kidneys, and histological correlates for kidneys and adrenals] in male and female mice from 13 different inbred strains. The latter were selected in order to have representatives from each major genealogical group and to conform to priorities set by the Mouse Phenome Database project. Inter-strain comparisons of phenotypes made it possible to identify strains that displayed values that belonged either to the low or the high end of the inter-strain variance for quantitative traits such as systolic blood pressure, body weight, left ventricular weight and/or adrenocortical structure. For instance, both male and female C3H/HeJ and A/J mice displayed either low systolic blood pressure or low cardiac ventricular mass, respectively, and male C57Bl6/J displayed low adrenal weights. Likewise, inter-sex comparisons made it possible to identify phenotypic values that were sexually dimorphic for some of the same traits. For instance, female AKR/J had relatively higher body weight and systolic blood pressure values than their male counterparts, and may constitute an animal model of the metabolic X syndrome. These strain- and sex-specific features will be of value either for future genetic and/or developmental studies or to develop new animal models that will help in the generation of mechanistic hypotheses. All data have been deposited to the Mouse Phenome Database for future integration with the Mouse Genome Database, and can be further analyzed and compared with tools available on the site.
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