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J Appl Physiol (March 22, 2002). doi:10.1152/japplphysiol.00072.2002
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Articles in PresS, published online ahead of print March 22, 2002
J Appl Physiol, 10.1152/jap.00072.2002
Submitted on January 29, 2002
Accepted on March 15, 2002

Spinoreticular Neurons Receiving Group III Input are Inhibited by MLR Stimulation

Alexandr M Degtyarenko1* and Marc P Kaufman1

1 Departments of Internal Medicine and Human Physiology, Division of Cardiovascular Medicine, University of California, Davis, Davis, CA, USA

* To whom correspondence should be addressed. E-mail: amdegt{at}ucdavis.edu.

In decerebrate paralyzed cats, we examined the responses of 18 spinoreticular neurons to electrical stimulation of the mesencephalic locomotor region (MLR). The activity of each of the spinoreticular neurons was recorded extracellularly from laminae IV through VI of the L7 and S1 spinal cord. In addition, each of the 18 spinoreticular neurons received group III afferent input from the tibial nerve. Spinoreticular projections were established for each of 18 neurons by antidromic invasion of the lateral reticular nucleus (LRN) at the P11 though P14 levels. The onset latencies and current thresholds for antidromic invasion from the LRN averaged 15.0 ± 3.8 ms and 117 ± 11 µA, respectively. Electrical stimulation of the MLR attenuated the spontaneous activity or the responses of each of the spinoreticular neurons to tibial nerve stimulation at currents that recruited group III afferents. Our data supports the notion that thin fiber muscle afferent input to the ventrolateral medulla is gated by a central command to exercise.




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