Journal of Applied Physiology Journal of Neurophysiology
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J Appl Physiol (April 5, 2007). doi:10.1152/japplphysiol.00071.2007
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Submitted on January 16, 2007
Accepted on March 30, 2007

Persistence of Eupnea and Gasping Following Blockade of Both Serotonin Type 1 and 2 Receptors in the In Situ Juvenile Rat Preparation.

Veronica A.L. Toppin1, Michael B. Harris2, Anna M Kober1, J. C. Leiter3, and Walter M. St.-John4*

1 Institute of Arctic Biology, University of Alaska, Fairbanks, Alaska, United States
2 Institute of Arctic Biology, University of Alaska, Fairbanks, Alaska, United States; Alaska basic Neuroscience Program, Univ of Alaska Fairbanks, Fairbanks, Alaska, United States
3 Physiology, Dartmouth Medical School, Lebanon, New Hampshire, United States
4 Dept. of Physiology, Dartmouth Medical School, Lebanon, United States

* To whom correspondence should be addressed. E-mail: walter.m.stjohn{at}dartmouth.edu.

In severe hypoxia or ischaemia, normal eupneic breathing is replaced by gasping which can serve as a powerful mechanism for "autoresuscitation." We have proposed that gasping is generated by medullary neurons having intrinsic pacemaker bursting properties dependent upon a persistent sodium current. A number of neuromodulators, including serotonin, influence persistent sodium currents. Thus, we hypothesized that endogenous serotonin is essential for gasping to be generated. To assess such a critical role for serotonin, a preparation of the perfused, juvenile in situ rat was used. Activities of the phrenic, hypoglossal and vagal nerves were recorded. We added blockers of type 1 and/or type 2 classes of serotonergic receptors to the perfusate delivered to the preparation. Eupnea continued following additions of any of the blockers. Changes were limited to an increase in the frequency of phrenic bursts and a decline in peak heights of all neural activities. In ischaemia, gasping was induced following any of the blockers. Few statistically significant changes in parameters of gasping were found. We thus did not find a differential suppression of gasping, compared to eupnea, following blockers of serotonin receptors. Such a differential suppression had been proposed based upon findings using an in vitro preparation. We hypothesize that multiple neurotransmitters/neuromodulators influence medullary mechanisms underlying the neurogenesis of gasping. In greatly reduced in vitro preparations, the importance of any remaining neuromodulators, such as serotonin, may be exaggerated compared to its role in more intact preparations.




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