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J Appl Physiol (October 25, 2002). doi:10.1152/japplphysiol.00059.2001
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Articles in PresS, published online ahead of print October 25, 2002
J Appl Physiol, 10.1152/jap.00059.2001
Submitted on January 25, 2001
Accepted on October 17, 2002

Effects of various forms of surfactant protein C on tidal volume in ventilated immature newborn rabbits

Katsumi Tashiro1*, Keisuke Ohta1, Xiaoguang Cui1, Kazuo Nishizuka1, Ken Yamamoto1, Tomoharu Konzaki1, Tsutomu Kobayashi1, and Yasuhiro Suzuki2

1 Deprtement of Anesthesiology and Intensive Care Medicine, GraduateSchool of Medicine, Kanazawa Universtity, Kanazawa, Japan
2 Department of Ultramicrostructural Research, Institute for Frontier Medical Science, Kyoto University, Kyoto, Japan

* To whom correspondence should be addressed. E-mail: tashirk{at}med.kanazawa-u.ac.jp.

Surfactant protein C (SP-C) is characterized by {alpha}-helix structure and palmitoyl groups attached to two cysteine residues. We examined the function of palmitoylation and dimerization in promotion of tidal volume in immature newborn rabbits. Reconstituted surfactants were made from a mixture of synthetic phospholipids and porcine SP-B (basic mixture) by adding various forms of SP-Cs: normal SP-C (nSP-C) isolated from porcine lungs, monomeric (mSP-Cpap) or dimeric (dSP-Cpap) forms of SP-C. These latter two were isolated from patients with pulmonary alveolar proteinosis and were less palmitoylated. Animals were ventilated at an inspiratory pressure of 25 cmH2O. Median tidal volumes were <2 ml/kg in non-treated controls, 7.7 ml/kg in animals receiving the basic mixture without SP-C, and >18 ml/kg in animals treated with reconstituted surfactants containing 3% nSP-C or 2% dSP-Cpap (P<0.05 vs. basic mixture). The physiological effect of basic mixture was not improved by mSP-Cpap. We conclude that palmitoyl groups are important for the physiological effects of SP-C, and that the dimeric form also improves physiological effects.




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