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Articles in PresS, published online ahead of print July 12, 2002
J Appl Physiol, 10.1152/jap.00053.2002
Submitted on January 22, 2002
Accepted on July 2, 2002
1 Biological Sciences, California State Polytechnic University, Pomona, CA, USA
2 Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA
3 Department of Physiology and Biophysics and Department of Orthopaedics, College of Medicine, University of California, Irvine, Irvine, CA, USA
4 Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA; Physiological Sciences Department, University of California, Los Angeles, Los Angeles, CA, USA
* To whom correspondence should be addressed. E-mail: rjtalmadge{at}csupomona.edu.
The effects of a complete spinal cord transection (ST) on the mechanical properties of the rat soleus were assessed 3 and 6 months post-ST and compared to age-matched controls. Maximal tetanic force was reduced by ~44% and ~25% at 3 and 6 months post-ST, respectively. Similarly, maximum twitch force was reduced by ~29% in 3-month and ~17% in 6-month ST rats. ST resulted in faster twitch properties as evidenced by shorter time-to-peak tension (~45%) and half relaxation times (~55%) at both time points. Maximum shortening velocity was significantly increased in ST rats whether measured by extrapolation from the force-velocity curve (~2-fold at both time points) or by slack-test measurements (over 2-fold at both time points). A significant reduction in fatigue resistance of the soleus was observed at 3 (~25%) and 6 months (~45%) post-ST. For the majority of the speed-related properties, no significant differences were detected between 3 and 6-month ST rats. However, the fatigue resistance of the soleus was significantly lower in 6- vs. 3-month ST rats. These data suggest that between 3 and 6 months post-ST, force-related properties tended to recover, speed-related properties plateaued, and fatigue-related properties continued to decline. Thus, some specific functional properties of the rat soleus related to contractile force, speed and fatigue adapted independently following ST.
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