| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Western Australia Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Baltimore, Maryland, United States
2 Pulmonary & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States
3 Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States
4 Medicine, Johns Hopkins University, Baltimore, Maryland, United States; Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States
5 Division of Pediatric Pulmonary Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States; Division of Pulmonary and Critical Care Medicine, Johns Hopkins Hospital, 5501 Hopkins Bayview Circle, Baltimore, Maryland, 21224, United States
6 Department of Surgery, Johns Hopkins School of Medicine, United States
7 Pulmonary & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States; Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States
* To whom correspondence should be addressed. E-mail: spatil{at}jhmi.edu.
Male gender, obesity and age are risk factors for obstructive sleep apnea, although the mechanisms by which these factors increase sleep apnea susceptibility are not entirely understood. This study examined the interrelationships between sleep apnea risk factors, upper airway mechanics and sleep apnea susceptibility. In 164 (86 men, 78 women) participants with and without sleep apnea, upper airway pressure-flow relationships were characterized to determine its mechanical properties (passive PCRIT) during non-rapid eye movement sleep. In multiple linear regression analyses, the effects of body-mass index and age on passive PCRIT were determined in each sex. A subset of men and women matched by body-mass index, age and disease severity was used to determine the sex effect on passive PCRIT. The passive PCRIT was 1.9 cmH2O (95% CI: 0.1-3.6 cmH2O) lower in women than men after matching for body-mass index, age and disease severity. The relationship between passive PCRIT and sleep apnea status and severity was examined. Sleep apnea was largely absent in those individuals with a passive PCRIT < -5 cm H2O and increased markedly in severity when passive PCRIT rose above -5 cm H2O. Passive PCRIT had a predictive power of 0.73 (95% CI: 0.65 - 0.82) in predicting sleep apnea status. Upper airway mechanics are differentially controlled by sex, obesity, and age, and partly mediate the relationship between these sleep apnea risk factors and obstructive sleep apnea.
This article has been cited by other articles:
|
|
 |
|
  M. Younes Role of respiratory control mechanisms in the pathogenesis of obstructive sleep disorders J Appl Physiol, November 1, 2008; 105(5): 1389 - 1405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Levitzky Using the pathophysiology of obstructive sleep apnea to teach cardiopulmonary integration Advan Physiol Educ, September 1, 2008; 32(3): 196 - 202. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
