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1 Division of Sleep Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA
* To whom correspondence should be addressed. E-mail: lling{at}partners.org.
This study examined the effect of chronic intermittent hypoxia (CIH: 5 min 11-12% O2/5 min air, 12 h/night, 7 nights) on ventilatory long-term facilitation (LTF) and determined the persistence period of this CIH-effect in awake rats. LTF, elicited by five or ten episodes of 5 min 12% O2, was measured 4 times in the same Sprague-Dawley rats by plethysmography, before and 8h, 3d and 7d after CIH-treatment. Resting ventilation was unchanged after CIH. Five episodes of 12% O2 did not initially elicit LTF but elicited LTF (23.5 ± 1.4% above baseline) 8h after CIH, which partially remained at 3d (11.4 ± 2.2%, P<0.05) and disappeared at 7d. Ten episodes initially elicited LTF (17.7 ± 1.1%, 45 min duration) and elicited an enhanced LTF (29.1 ± 1.5%, 75 min) 8h after CIH. These results demonstrated that CIH enhanced ventilatory LTF in conscious, freely behaving rats in 2 ways: 1) a previously ineffective protocol induced LTF. 2) LTF magnitude was increased and LTF duration prolonged, and this CIH-effect on LTF persisted for at least 3 days.
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