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J Appl Physiol (December 13, 2002). doi:10.1152/japplphysiol.00040.2002
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Articles in PresS, published online ahead of print December 13, 2002
J Appl Physiol, 10.1152/jap.00040.2002
Submitted on January 17, 2002
Accepted on December 3, 2002

Cardiovascular and splenic responses to exercise in humans

Ian B. Stewart1*, Darren E. R. Warburton2, Alastair N. H. Hodges3, Don Lyster4, and Donald C. McKenzie2

1 School of Human Movement Studies, Queensland University of Technology, Brisbane, QLD, Australia
2 School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada; Department of Medicine, University of British Columbia, Vancouver, BC, Canada
3 School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
4 Department of Medicine, University of British Columbia, Vancouver, BC, Canada

* To whom correspondence should be addressed. E-mail: i.stewart{at}qut.edu.au.

To investigate splenic erythrocyte volume following exercise and the effect on hematocrit and hemoglobin based plasma volume equations. 9 males cycled at an intensity of 60% VO2 max for 5, 10, or 15 minutes duration, followed by an incremental ride to exhaustion. The reduction in spleen volume, calculated using 99mTc labelled erythrocytes, was not significantly different between the three submaximal rides (5 min=28, 10 min=30, 15 min=36%; P=0.26). The incremental ride to exhaustion resulted in a 56% reduction in spleen volume, which recovered to baseline levels within 20 minutes. Plasma catecholamines were inversely related to spleen volume following exercise (r=0.70-0.84; P<0.0001). There were no differences in red cell or total blood volume pre- to post-exercise, however a significant reduction in plasma volume was observed (18.9%; P<0.01). There was no difference between the iodinated albumin and the hematocrit/hemoglobin methods of assessing plasma volume changes. These results suggest that the spleen regulates its volume in response to an intensity dependent signal and plasma catecholamines appear partially responsible. Splenic release of erythrocytes has no effect on indirect measures of plasma volume.




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