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Articles in PresS, published online ahead of print April 26, 2002
J Appl Physiol, 10.1152/jap.00035.2002
Submitted on January 16, 2002
Accepted on April 23, 2002
1 Center for the Study of Health Effects of Exercise in Children, University of California, Irvine, Orange, CA, USA
2 Departments of Psychiatry and Medicine, University of California, San Diego, San Diego, CA, USA
* To whom correspondence should be addressed. E-mail: dcooper{at}uci.edu.
We hypothesized that brief exercise of a small muscle group would lead to local rather than systemic alterations in cytokines, peripheral blood mononuclear cells, and mediators of angiogenesis. Fifteen men and 8 women (age range 22 to 36 years-old) performed 10 minutes of unilateral wrist flexion exercise. Blood was sampled from venous catheters in the resting and exercising arms. Lactate was significantly elevated in the exercising arm (+276±35 %, p<0.0005) with no change in the resting arm. In contrast, increases in both arms were observed for: interleukin-6 (+139±51 %, p<0.0005), growth hormone (+1104±284 %, p<0.003), natural killer cells (+81±9 %, p<0.0005), and lymphocytes expressing CD62, CD11 and CD54. There were no significant differences in these increases between the resting and exercising arm. Catecholamines increased in both arms (epinephrine peak increase, +226±36 %, p<0.001; norepinephrine peak increase, +90±15 %, p<0.01). Fibroblast growth factor-2 initially decreased with exercise in both arms, and this was followed by a rebound increase. Vascular endothelial growth factor demonstrated a small but significant increase in both arms (+124±31%, p<0.05). Brief, low-intensity exercise leads to a systemic rather than local response of mediators that could be involved in inflammation, repair, or angiogenic adaptation to physical activity.
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