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J Appl Physiol (December 20, 2002). doi:10.1152/japplphysiol.00018.2001
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Submitted on January 9, 2001
Accepted on September 6, 2002

Reduced respiratory-related evoked activity in subjects with obstructive sleep apnea syndrome

Metin Akay1, J. C. Leiter2, and J. Andrew Daubenspeck3*

1 Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
2 Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA; Department of Medicine, Dartmouth Medical School, Lebanon, NH, USA
3 Thayer School of Engineering, Dartmouth College, Hanover, NH, USA; Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA

* To whom correspondence should be addressed. E-mail: andrew.daubenspeck{at}dartmouth.edu.

Mid-latency respiratory related evoked potentials were measured during wakefulness using a 60 electrode array placed over the cortical region of the scalp. We studied the responses evoked by 200 msec pressure pulses at -5 and -10 cm H2O applied at inspiratory onset and during control tests (no pressure applied) in 14 subjects with obstructive sleep apnea syndrome (OSAS) and 18 normal subjects. Wavelet decomposition was used to smooth and dissect the RREPs in frequency and time in eight frequency bands. After denoising, selected wavelet scales were used to reconstruct the RREPs, which were quantified using global field power (GFP) estimates. The time course of the GFP activity in the OSAS subjects compared to normals was significantly depressed in the period 55-70 msec post-stimulus onset, a time when afferent traffic from upper airway receptors arrives in normal subjects. The reduced evoked response in subjects with OSAS suggests that these subjects receive less afferent input from upper airway mechanoreceptors. This may reflect reduced sensitivity of mechanoreceptors or reduced mechanoreceptor stimulation due to decreased upper airway compliance during wakefulness in OSAS.




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