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1 Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark
2 Turku PET Centre, University of Turku and Turku Central Hospital, Turku, Finland
* To whom correspondence should be addressed. E-mail: jbm01{at}bbh.hosp.dk.
The metabolic activity of tendinous tissues has traditionally been considered to be of limited magnitude. However, recent studies have suggested that glucose uptake increases in the force transmitting tissues as a response to contractile loading, which in turn indicates an elevated tissue metabolism. The purpose of the present study was to investigate if such a mechanism could be observed for the human Achilles tendon following tensile loading. Six subjects participated in the study. Unilateral Achilles tendon loading was applied by 25-min intermittent voluntary plantar flexor contractions. A radioactive tracer ([18F]-2-flouro-2-deoxy-D-glucose ([18F]FDG)) was administered during muscle action, and glucose uptake was measured by use of positron emission tomography (PET). Regions of interest (ROIs) were defined on the PET images corresponding to the cross section of Achilles tendon at two longitudinally separated sites (insertion, and free tendon). Glucose uptake index was determined within respective ROI's for the active and resting leg. Tendon force during voluntary contractions was ~13% of MVC force. Tendon loading induced an elevated glucose uptake index compared to that of the contralateral resting tendon in the region of tendon insertion (0.13 ± 0.05 vs. 0.09 ± 0.02, P<0.05) and at the free tendon (0.12 ± 0.01 vs. 0.08 ± 0.02, P<0.05). The present data suggest that tissue metabolism is elevated in the human Achilles tendon in response to low intensity loading.
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