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J Appl Physiol (October 11, 2002). doi:10.1152/japplphysiol.00004.2002
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Articles in PresS, published online ahead of print October 11, 2002
J Appl Physiol, 10.1152/jap.00004.2002
Submitted on January 7, 2002
Accepted on October 7, 2002

Exercise Increases Prolactin Receptor Expression on Human Lymphocytes

Keiichiro Dohi1, William J Kraemer2, and Andrea M Mastro3*

1 Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA
2 The Human Performance Laboratory, Department of Kinesiology and Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA
3 Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, PA, USA

* To whom correspondence should be addressed. E-mail: a36{at}psu.edu.

Plasma prolactin has been shown to increase during stress; the immune system is responsive to prolactin and affected by stress. Therefore, this study was undertaken to investigate the effects of acute graded, maximal treadmill exercise on prolactin receptor expression by lymphocytes. Eight healthy men underwent one exercise and one nonexercise session. Blood was sampled immediately before and after the exercise. On the day of the nonexercise session, two resting blood samples were obtained at the same times as the exercise session samples to act as baseline data. Plasma prolactin concentrations were significantly elevated in response to exercise and correlated positively with total prolactin receptor expression per B lymphocyte. An increase in total prolactin receptor expression per B Lymphocyte in response to exercise also was observed. In addition, exercise significantly increased the total number of circulating B lymphocytes expressing prolactin receptor as well as the total number of circulating B lymphocytes. These data support the idea that exercise may enhance the interaction between immune target cells and prolactin, a stress hormone capable of enhancing immunity.






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