Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol (March 15, 2002). doi:10.1152/japplphysiol.00002.2002
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Articles in PresS, published online ahead of print March 15, 2002
J Appl Physiol, 10.1152/jap.00002.2002
Submitted on January 4, 2002
Accepted on February 20, 2002

IGF-l, IgA and IgG responses to bovine colostrum supplementation during training

Antti Mero1*, Jonne Kahkonen1, Tarja Nykanen1, Tapani Parviainen2, Ilmari Jokinen3, Timo Takala1, Tuomo Nikula4, Simo Rasi5, and Juhani Leppaluoto5

1 Department of Biology of Physical Activity, University of Jyvaskyla, Jyvaskyla, Finland
2 Department of Clinical Physiology, Central Hospital of Central Finland, Jyvaskyla, Finland
3 Department of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla, Finland
4 Department of Technology, Map Medical Technologies Oy, Tikkakoski, Finland
5 Department of Physiology, University of Oulu, Oulu, Finland

* To whom correspondence should be addressed. E-mail: mero{at}maila.jyu.fi.

This study examined the effect of bovine colostrum (DynamicTM Colostrum) supplementation on blood and saliva variables (study 1) and the absorption of orally administered human recombinant IGF-1 (rhIGF-1) labeled with 123 iodine (study 2). In study 1 adult male and female athletes were randomly assigned in a double-blind fashion to either an experimental (Dynamic; n=19) or a control (Placebo; n=11) group, the former consumed daily 20 g Dynamic supplement and the latter 20 g maltodextrin during a 2 week training period. After bovine colostrum supplementation significant increases were noticed in serum IGF-1 (p < 0.01) and saliva IgA (p < 0.01) in Dynamic compared with Placebo. In study 2 gel electrophoresis was carried out in 12 adult subjects with serum samples taken at 60 min after ingestion of 123 I-rhIGF-1 and showed peaks at 0.6-kDa and at 40 - 90-kDa, the former inducing 96% and the latter 4% of the total radioactivity. It was concluded that a long-term supplementation of bovine colostrum (Dynamic) increases serum IGF-1 and saliva IgA concentration in athletes during training. Absorption data shows that ingested 123I-rhIGF-1 is fragmented in circulation and no radioactive IGF-1 is eluted at the positions of free or the IGF binding proteins giving no support to the absorption of IGF-1 from bovine colostrum.




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