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J Appl Physiol 105: 392, 2008; doi:10.1152/japplphysiol.90489.2008
8750-7587/08 $8.00
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LETTER TO THE EDITOR

Dividing the FEV1 into its component parts

TO THE EDITOR: Sorkness et al. (1) show that the forced expiratory volume in 1 s (FEV1) expressed as percent predicted can be broken down into its two components, forced vital capacity (FVC) and FEV1/FVC, also expressed as percent predicted. They claim that "this is a novel approach [for partitioning the FEV1] in a quantitative manner". In fact, this quantitative novelty was introduced 12 years ago by Gibbons et al. (2) for exactly the same reason that Sorkness et al. (1) use it: to detect asthmatic subjects with severe disease. Sorkness et al. suggest that severe asthmatic subjects may be fundamentally different from nonsevere asthmatic subjects in that they have airway closure, causing gas trapping, and this can be detected by a lower FVC in the severe group. If so, the frequency distribution of fall in FVC at the dose of agonist producing a 20% decline in FEV1 (PC20) should be bimodal. However, Gibbons et al. (2) found that in 146 asthmatic subjects, this distribution was unimodal and normally distributed. It could be claimed that the numbers were insufficient to demonstrate bimodality, but 64 of the 146 patients had a fall in FVC ≥ 15%, accounting for 75% or more of the fall in FEV1.

Curiously, in a control group of only 20 healthy subjects receiving high-dose methacholine challenge, there was clear evidence of bimodality: 16 subjects had a fall in FVC ranging from 0 to 15% and there were none between 15 and 19.9% but 4 between 20 and 55%. Could it be that these four subjects were at risk for developing asthma?

Sorkness et al. (1) did not report the fall in FVC at the PC20, and their subjects were preselected as either severe or nonsevere asthma. This selection would prevent detection of bimodality; an unselected group of patients like those studied by Gibbons et al. (2) would be required. Sorkness et al. (1) claim that their study "is the first ... to show the predilection of severe asthma for air trapping over the entire range of airflow limitation," but the asthmatic subjects studied by Gibbons et al. had a mean baseline value of FVC and FEV1 of 105.7% and 98.9% predicted, respectively, with lower 95% confidence limits of 76.9% and 70.1% predicted, respectively, so the claim of Sorkness et al. to originality can be challenged. Finally, Gibbons et al. found no correlation between PC20 and percent fall in FVC at the PC20, proving that sensitivity to methacholine and response to the agonist are unrelated phenomena.

FOOTNOTES


Address for reprint requests and other correspondence: P. T. Macklem, P. O. Box 250, Lansdowne, Ontario, Canada K0E 1L0 (e-mail: peter.macklem{at}gmail.com)

REFERENCES

  1. Sorkness RL, Bleeker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Erzurum SC, Gaston BM, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Wenzel SE, for the National Hearth, Lung, and Blood Institute Severe Asthma Research Program. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol 104: 394–403, 2008.[Abstract/Free Full Text]
  2. Gibbons WJ, Sharma A, Lougheed D, Macklem PT. Detection of excessive bronchoconstriction in asthma. Am J Respir Crit Care Med 153: 582–589, 1996.[Abstract]

Peter T. Macklem1
Charles G. Irvin2
 1Meakins-Christie Laboratories, McGill University Health Centre Research Institute, Montreal, Quebec; and 2Department of Medicine, University of Vermont, Burlington, Vermont




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J Appl Physiol, July 1, 2008; 105(1): 393 - 393.
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