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INVITED REVIEW

HIGHLIGHTED TOPICS
Physiology and Pathophysiology of Sleep Apnea

Influence of cardiac function and failure on sleep-disordered breathing: evidence for a causative role

¹Divisions of Pulmonary and Critical Care Medicine and ²Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota

Heart failure is an increasingly common public health problem that is strongly linked to both central and obstructive sleep apnea, collectively referred to as sleep-disordered breathing. Much attention has been given to the deleterious effects of sleep-disordered breathing on the failing heart and potential mechanisms by which treatment of sleep-disordered breathing may result in improved cardiac performance and long-term outcomes. However, there is compelling evidence that cardiac dysfunction may contribute to sleep-disordered breathing. Although there is recognized overlap between pathophysiological mechanisms in central sleep apnea and obstructive sleep apnea, data supporting the role of cardiac function are certain forms of central sleep apnea are well established, whereas investigation into the relationship with obstructive sleep apnea is less mature but continues to evolve. This review will examine experimental and observational data that explore possible pathophysiological mechanisms and potential targets for therapy in heart failure and sleep-disordered breathing.

obstructive sleep apnea; central sleep apnea

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