HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 99/5/1676    most recent 00641.2005v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (15) Citing Articles via Google Scholar Google Scholar Articles by Schou, M. Articles by Secher, N. H. Search for Related Content PubMed PubMed Citation Articles by Schou, M. Articles by Secher, N. H.

Kidneys extract BNP and NT-proBNP in healthy young men

¹Department of Cardiology and Endocrinology, Frederiksberg University Hospital, Frederiksberg; and Departments of ³Anesthesiology, ²Hepatology, and ⁴Cardiology and ⁵The Copenhagen Muscle Research Center, Copenhagen University Hospital, Copenhagen, Denmark

Submitted 30 May 2005 ; accepted in final form 18 July 2005

Renal metabolism of the cardiac marker NH₂-terminal-pro-brain natriuretic peptide (NT-proBNP) has been suggested. Therefore, we determined the renal extraction ratios of NT-proBNP and its bioactive coproduct brain natriuretic peptide (BNP) at rest and during exercise. In addition, the cerebral ratios were evaluated. Ten young healthy men were investigated at baseline, during moderate cycle exercise (heart rate: 140, Borg scale: 14–15), and in the recovery with BNP and NT-proBNP measured from the brachial artery and the jugular and renal veins, and the renal and cerebral extraction ratios (Ext-Ren and Ext-Cer, respectively) were calculated. Cardiac output, stroke volume, heart rate, mean arterial pressures, and estimated glomerular filtration were determined. BNP and NT-proBNP were extracted by the kidneys but not by the brain. We observed no effect of exercise. The mean values (± SE) of Ext-Ren of NT-proBNP were similar (0.19 ± 0.05, 0.21 ± 0.06, and 0.12 ± 0.03, respectively) during the three sessions (P > 0.05). Also the Ext-Ren of BNP were similar (0.18 ± 0.07, 0.15 ± 0.11, and 0.14 ± 0.06, respectively; P > 0.05). There were no significant differences between Ext-Ren of BNP and NT-proBNP during the three sessions (P > 0.05). The Ext-Cer of both peptides varied insignificantly between –0.21 ± 0.15 and 0.11 ± 0.08. The renal extraction ratio of both BNP and NT-proBNP is 0.15–0.20. There is no cerebral extraction, and short-term moderate exercise does not affect these values. Our findings suggest that the kidneys extract BNP and NT-proBNP to a similar extent in healthy young men.

brain natriuretic peptide; NH₂-terminal-pro-brain natriuretic peptide; renal extraction ratio

This article has been cited by other articles:

				G. C.M. Linssen, K. Damman, H. L. Hillege, G. Navis, D. J. van Veldhuisen, and A. A. Voors Urinary N-Terminal Prohormone Brain Natriuretic Peptide Excretion in Patients With Chronic Heart Failure Circulation, July 7, 2009; 120(1): 35 - 41. [Abstract] [Full Text] [PDF]

				R. R.J. van Kimmenade, J. L. Januzzi Jr, J. A. Bakker, A. J. Houben, R. Rennenberg, A. A. Kroon, H. J.G.M. Crijns, M. P. van Dieijen-Visser, P. W. de Leeuw, and Y. M. Pinto Renal clearance of B-type natriuretic peptide and amino terminal pro-B-type natriuretic peptide a mechanistic study in hypertensive subjects. J. Am. Coll. Cardiol., March 10, 2009; 53(10): 884 - 890. [Abstract] [Full Text] [PDF]

				S. C. Palmer and A. M. Richards Does renal clearance differ between the B-type natriuretic peptides (BNP versus NT-proBNP)? J. Am. Coll. Cardiol., March 10, 2009; 53(10): 891 - 892. [Full Text] [PDF]

				S. Vickery, M. C. Webb, C. P. Price, R. I. John, N. A. Abbas, and E. J. Lamb Prognostic value of cardiac biomarkers for death in a non-dialysis chronic kidney disease population Nephrol. Dial. Transplant., November 1, 2008; 23(11): 3546 - 3553. [Abstract] [Full Text] [PDF]

				N. H. Secher, T. Seifert, and J. J. Van Lieshout Cerebral blood flow and metabolism during exercise: implications for fatigue J Appl Physiol, January 1, 2008; 104(1): 306 - 314. [Abstract] [Full Text] [PDF]

				C. R. deFilippi, S. L. Seliger, S. Maynard, and R. H. Christenson Impact of Renal Disease on Natriuretic Peptide Testing for Diagnosing Decompensated Heart Failure and Predicting Mortality Clin. Chem., August 1, 2007; 53(8): 1511 - 1519. [Abstract] [Full Text] [PDF]

				S. Choi, D. Park, S. Lee, Y. Hong, S. Kim, and J. Lee Cut-off values of B-type natriuretic peptide for the diagnosis of congestive heart failure in patients with dyspnoea visiting emergency departments: a study on Korean patients visiting emergency departments Emerg. Med. J., May 1, 2007; 24(5): 343 - 347. [Abstract] [Full Text] [PDF]

				J. L. Januzzi, D. M. Lloyd-Jones, and S. Anwaruddin Reply J. Am. Coll. Cardiol., September 5, 2006; 48(5): 1061 - 1061. [Full Text] [PDF]

				S. Masson, R. Latini, I. S. Anand, T. Vago, L. Angelici, S. Barlera, E. D. Missov, A. Clerico, G. Tognoni, J. N. Cohn, et al. Direct Comparison of B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP in a Large Population of Patients with Chronic and Symptomatic Heart Failure: The Valsartan Heart Failure (Val-HeFT) Data Clin. Chem., August 1, 2006; 52(8): 1528 - 1538. [Abstract] [Full Text] [PDF]