HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 99/5/1636    most recent 00464.2005v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Samson, N. Articles by Praud, J.-P. Search for Related Content PubMed PubMed Citation Articles by Samson, N. Articles by Praud, J.-P.

INVITED EDITORIAL

Effect of nasal continuous or intermittent positive airway pressure on nonnutritive swallowing in the newborn lamb

Neonatal Respiratory Research Unit, Departments of Pediatrics and Physiology, University of Sherbrooke, Sherbrooke, Quebec, Canada

Submitted 22 April 2005 ; accepted in final form 22 June 2005

The present study was aimed at investigating the effects of nasal continuous positive airway pressure (nCPAP; 6 cmH₂O) or intermittent positive pressure ventilation (nIPPV; 10/4 cmH₂O) on nonnutritive swallowing (NNS) and on the coordination between NNS and phases of the respiratory cycle, while taking into account the potential effects of states of alertness. Twelve full-term lambs were chronically instrumented at 48 h after birth for polysomnographic recordings, including NNS, diaphragm electromyographic activity, respiratory movements, pulse oximetry, and states of alertness. Studies in control conditions, with nCPAP and nIPPV, were performed in random order in nonsedated lambs at 4, 5, and 6 days of life. Results demonstrate that nCPAP significantly decreased overall NNS frequency, more specifically isolated NNS during quiet sleep and bursts of NNS in active sleep. In comparison, the effects of nIPPV on NNS frequency were more variable, with an inhibition of NNS only in wakefulness and an increase in isolated NNS frequency in active sleep. In addition, neither nCPAP nor nIPPV disrupted the coordination between NNS and phases of the respiratory cycle. In conclusion, nCPAP inhibits NNS occurrence in newborn lambs. Clinical relevance of this novel finding is related to the importance of NNS for clearing the upper airways from secretions and gastric content frequently regurgitated in the neonatal period.

control of breathing; sleep; radiotelemetry; upper airways; larynx

This article has been cited by other articles:

				C. Duvareille, M. Lafrance, N. Samson, M. St-Hilaire, P. Pladys, P. Micheau, V. Bournival, C. Langlois, and J.-P. Praud Effects of hypoxia and hypercapnia on nonnutritive swallowing in newborn lambs J Appl Physiol, October 1, 2007; 103(4): 1180 - 1188. [Abstract] [Full Text] [PDF]

				F. Moreau-Bussiere, N. Samson, M. St-Hilaire, P. Reix, J. R. Lafond, E. Nsegbe, and J.-P. Praud Laryngeal response to nasal ventilation in nonsedated newborn lambs J Appl Physiol, June 1, 2007; 102(6): 2149 - 2157. [Abstract] [Full Text] [PDF]