Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 99: 1600-1606, 2005; doi:10.1152/japplphysiol.00501.2005
8750-7587/05 $8.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Patel, S. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Patel, S. R.

INVITED REVIEW

HIGHLIGHTED TOPICS
Physiology and Pathophysiology of Sleep Apnea

Shared genetic risk factors for obstructive sleep apnea and obesity

Sanjay R. Patel

Division of Sleep Medicine, Brigham and Women’s Hospital, Boston, Massachusetts

Both obesity and obstructive sleep apnea (OSA) are complex disorders with multiple risk factors, which interact in a complicated fashion to determine the overall phenotype. In addition to environmental risk factors, each disorder has a strong genetic basis that is likely due to the summation of small to moderate effects from a large number of genetic loci. Obesity is a strong risk factor for sleep apnea, and there are some data to suggest sleep apnea may influence obesity. It is therefore not surprising that many susceptibility genes for obesity and OSA should be shared. Current research suggests that approximately half of the genetic variance in the apnea hypopnea index is shared with obesity phenotypes. Genetic polymorphisms that increase weight will also be risk factors for apnea. In addition, given the interrelated pathways regulating both weight and other intermediate phenotypes for sleep apnea such as ventilatory control, upper airway muscle function, and sleep characteristics, it is likely that there are genes with pleiotropic effects independently impacting obesity and OSA traits. Other genetic loci likely interact with obesity to influence development of OSA in a gene-by-environment type of effect. Conversely, environmental stressors such as intermittent hypoxia and sleep fragmentation produced by OSA may interact with obesity susceptibility genes to modulate the importance that these loci have on defining obesity-related traits.

susceptibility genes; pleiotropy; gene x environment effects


Address for reprint requests and other correspondence: S. R. Patel, BWH Sleep Disorders Program at BIDMC, Brigham and Women’s Hospital, 75 Francis St., Boston, MA 02115 (e-mail: spatel{at}partners.org)




This article has been cited by other articles:


Home page
 Eur Respir JHome page
H. Schneider, V. Krishnan, L. E. Pichard, S. P. Patil, P. L. Smith, and A. R. Schwartz
Inspiratory duty cycle responses to flow limitation predict nocturnal hypoventilation
Eur. Respir. J., May 1, 2009; 33(5): 1068 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. R. Schwartz, S. P. Patil, H. Schneider, and P. L. Smith
Modelling pathogenic mechanisms of upper airway dysfunction in the molecular age
Eur. Respir. J., August 1, 2008; 32(2): 255 - 258.
[Full Text] [PDF]

Home page
 ChestHome page
M. Kalra, R. Chakraborty, M. Hanaoka, and K. Kubo
Leptin and Leptin Receptor Gene Polymorphisms in Obstructive Sleep Apnea Syndrome
Chest, June 1, 2008; 133(6): 1530 - 1531.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
D. J. Eckert and A. Malhotra
Pathophysiology of Adult Obstructive Sleep Apnea
Proceedings of the ATS, February 15, 2008; 5(2): 144 - 153.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
A. R. Schwartz, S. P. Patil, A. M. Laffan, V. Polotsky, H. Schneider, and P. L. Smith
Obesity and Obstructive Sleep Apnea: Pathogenic Mechanisms and Therapeutic Approaches
Proceedings of the ATS, February 15, 2008; 5(2): 185 - 192.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Pierola, A. Barcelo, M. de la Pena, F. Barbe, J. B. Soriano, A. Sanchez Armengol, C. Martinez, and A. Agusti
{beta}3-Adrenergic receptor Trp64Arg polymorphism and increased body mass index in sleep apnoea
Eur. Respir. J., October 1, 2007; 30(4): 743 - 747.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Parati, C. Lombardi, and K. Narkiewicz
Sleep apnea: epidemiology, pathophysiology, and relation to cardiovascular risk
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1671 - R1683.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
W. T. McNicholas, M. R. Bonsignore, and the Management Committee of EU COST ACTION B26
Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities
Eur. Respir. J., January 1, 2007; 29(1): 156 - 178.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
V. Y. Polotsky and C. P. O'Donnell
Genomics of Sleep-disordered Breathing
Proceedings of the ATS, January 1, 2007; 4(1): 121 - 126.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. Lydic
Sleep disruption is related to allelic variation in the ob gene
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R892 - R893.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the American Physiological Society.