HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 99/4/1523    most recent 00177.2005v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Olufsen, M. S. Articles by Novak, V. Search for Related Content PubMed PubMed Citation Articles by Olufsen, M. S. Articles by Novak, V.

Blood pressure and blood flow variation during postural change from sitting to standing: model development and validation

¹Department of Mathematics, North Carolina State University, Raleigh, North Carolina; ²Department of Mathematics and Physics, Roskilde University, Roskilde, Denmark; and ³Hebrew SeniorLife, Research and Training Institute, and ⁴Division of Gerontology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts

Submitted 14 February 2005 ; accepted in final form 26 April 2005

Short-term cardiovascular responses to postural change from sitting to standing involve complex interactions between the autonomic nervous system, which regulates blood pressure, and cerebral autoregulation, which maintains cerebral perfusion. We present a mathematical model that can predict dynamic changes in beat-to-beat arterial blood pressure and middle cerebral artery blood flow velocity during postural change from sitting to standing. Our cardiovascular model utilizes 11 compartments to describe blood pressure, blood flow, compliance, and resistance in the heart and systemic circulation. To include dynamics due to the pulsatile nature of blood pressure and blood flow, resistances in the large systemic arteries are modeled using nonlinear functions of pressure. A physiologically based submodel is used to describe effects of gravity on venous blood pooling during postural change. Two types of control mechanisms are included: 1) autonomic regulation mediated by sympathetic and parasympathetic responses, which affect heart rate, cardiac contractility, resistance, and compliance, and 2) autoregulation mediated by responses to local changes in myogenic tone, metabolic demand, and CO₂ concentration, which affect cerebrovascular resistance. Finally, we formulate an inverse least-squares problem to estimate parameters and demonstrate that our mathematical model is in agreement with physiological data from a young subject during postural change from sitting to standing.

cardiovascular system; mathematical modeling; cerebral blood flow; gravitational effect; autonomic regulation; cerebral autoregulation

This article has been cited by other articles:

				R. A. I. Lucas, J. D. Cotter, S. Morrison, and P. N. Ainslie The effects of ageing and passive heating on cardiorespiratory and cerebrovascular responses to orthostatic stress in humans Exp Physiol, October 1, 2008; 93(10): 1104 - 1117. [Abstract] [Full Text] [PDF]

				J. Y. A. Foo Bilateral Transit Time Assessment of Upper and Lower Limbs as a Surrogate Ankle Brachial Index Marker Angiology, July 1, 2008; 59(3): 283 - 289. [Abstract] [PDF]

				H. M. Stauss Power spectral analysis in mice: what are the appropriate frequency bands? Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R902 - R903. [Full Text] [PDF]

				M. S. Olufsen, H. T. Tran, J. T. Ottesen, Research Experiences for Undergraduates Program, L. A. Lipsitz, and V. Novak Modeling baroreflex regulation of heart rate during orthostatic stress Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1355 - R1368. [Abstract] [Full Text] [PDF]

				K. van Heusden, J. Gisolf, W. J. Stok, S. Dijkstra, and J. M. Karemaker Mathematical modeling of gravitational effects on the circulation: importance of the time course of venous pooling and blood volume changes in the lungs Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2152 - H2165. [Abstract] [Full Text] [PDF]