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Effects of prior heavy-intensity exercise during single-leg knee extension on O₂ kinetics and limb blood flow

¹Canadian Centre for Activity and Aging, ²School of Kinesiology, and ³Department of Physiology and Pharmacology, The University of Western Ontario, London, Canada

Submitted 10 February 2005 ; accepted in final form 9 May 2005

The effects of prior heavy-intensity exercise on O₂ uptake (O₂) kinetics of a second heavy exercise may be due to vasodilation (associated with metabolic acidosis) and improved muscle blood flow. This study examined the effect of prior heavy-intensity exercise on femoral artery blood flow (Qleg) and its relationship with O₂ kinetics. Five young subjects completed five to eight repeats of two 6-min bouts of heavy-intensity one-legged, knee-extension exercise separated by 6 min of loadless exercise. O₂ was measured breath by breath. Pulsed-wave Doppler ultrasound was used to measure Qleg. O₂ and blood flow velocity data were fit using a monoexponential model to identify phase II and phase III time periods and estimate the response amplitudes and time constants (). Phase II O₂ kinetics was speeded on the second heavy-intensity exercise [mean (SD), 29 (10) s to 24 (10) s, P < 0.05] with no change in the phase II (or phase III) amplitude. Qleg was elevated before the second exercise [1.55 (0.34) l/min to 1.90 (0.25) l/min, P < 0.05], but the amplitude and time course [, 25 (13) s to 35 (13) s] were not changed, such that throughout the transient the Qleg (and Qleg/O₂) did not differ from the prior heavy exercise. Thus O₂ kinetics were accelerated on the second exercise, but the faster kinetics were not associated with changes in Qleg. Thus limb blood flow appears not to limit O₂ kinetics during single-leg heavy-intensity exercise nor to be the mechanism of the altered O₂ response after heavy-intensity prior exercise.

femoral artery blood flow; priming exercise; oxygen uptake; primary component O₂ kinetics

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