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This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 99/4/1397    most recent 00435.2005v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by Hasegawa, H. Articles by Michotte, Y. Search for Related Content PubMed PubMed Citation Articles by Hasegawa, H. Articles by Michotte, Y.

Acute dopamine/norepinephrine reuptake inhibition increases brain and core temperature in rats

¹Department of Human Physiology and Sportsmedicine, and ²Experimental Pharmacology Research Group, Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Brussels, Belgium; ³Department of Human Movement and Sport Sciences, Istituto Universitario di Scienze Motorie, Rome, Italy; and ⁴Laboratory of Exercise Physiology, Faculty of Integrated Arts and Sciences, Hiroshima University, Kagamiyama, Higashihiroshima, Japan

Submitted 18 April 2005 ; accepted in final form 24 May 2005

The purpose of the present study was to examine the effects of an acute dose of the dual dopamine (DA) and norepinephrine (NE) reuptake inhibitor bupropion (Bup) on brain (T_brain), body core (T_core), and tail skin (T_tail) temperature in freely moving rats and to simultaneously monitor the extracellular neurotransmitter concentrations in the preoptic area and anterior hypothalamus (PO/AH). A microdialysis probe was inserted in the PO/AH, and samples for NE, DA, and serotonin (5-HT) were collected every 20 min before and after the injection of 17 mg/kg of Bup, for a total sampling time of 180 min. T_core was monitored using a biotelemetry system. T_brain and T_tail, an index of heat loss response, were also measured. Both NE and DA levels in the PO/AH significantly increased after Bup injection compared with the baseline levels, reaching 450 and 230%, respectively, 40 min after injection. There was no effect on 5-HT release. The neurotransmitter changes were accompanied by a significant decrease in T_tail and an increase in both T_brain and T_core compared with the baseline levels. The present results demonstrate that inhibition of NE and DA reuptake suppresses heat loss mechanisms and elevates T_brain and T_core in freely moving rats.

microdialysis; monoamines; preoptic area and anterior hypothalamus; body temperature

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