Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 99: 1301-1307, 2005. First published June 2, 2005; doi:10.1152/japplphysiol.00192.2005
8750-7587/05 $8.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
99/4/1301    most recent
00192.2005v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by De Troyer, A.
Right arrow Articles by Scillia, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Troyer, A.
Right arrow Articles by Scillia, P.

Effect of inflation on the interaction between the left and right hemidiaphragms

André De Troyer,1,2 Matteo Cappello,1,2 and Pierre Scillia1,3

1Laboratory of Cardiorespiratory Physiology, Brussels School of Medicine, and 2Chest Service and 3Department of Radiology, Erasme University Hospital, Brussels, Belgium

Submitted 16 February 2005 ; accepted in final form 6 May 2005

At resting end expiration [functional residual capacity (FRC)], the actions of the left and right hemidiaphragms on the lung are synergistic. However, the synergism decreases in magnitude as muscle tension decreases. Therefore, the hypothesis was tested in anesthetized dogs that the degree of synergism between the two hemidiaphragms also decreases with increasing lung volume. In a first experiment, the changes in airway opening pressure ({Delta}Pao) and abdominal pressure ({Delta}Pab) obtained during simultaneous stimulation of the left and right phrenic nerves (measured changes in pressure) at different lung volumes were compared with the sum of the pressure changes produced by their separate stimulation (predicted changes in pressure). Although the pressure changes decreased markedly with increasing lung volume, the measured {Delta}Pao and {Delta}Pab were substantially greater than the predicted values at all lung volumes. The ratio of the measured to the predicted {Delta}Pao, in fact, remained constant. In a second experiment, radiographic measurements showed that the fractional shortening of the muscle during bilateral contraction at high lung volumes was similar to that during unilateral contraction. During unilateral contraction at high lung volumes, however, the passive hemidiaphragm moved in the cranial direction, whereas, during unilateral contraction at FRC, it moved in the caudal direction. These observations indicate that 1) for a given muscle tension, the synergism between the two halves of the diaphragm is greater at high lung volumes than at FRC; and 2) this difference is primarily related to the greater distortion of the muscle configuration.

respiratory muscles; diaphragm mechanics; mechanics of breathing


Address for reprint requests and other correspondence: A. De Troyer, Chest Service, Erasme Univ. Hospital, Route de Lennik, 808, 1070 Brussels, Belgium (e-mail: a_detroyer{at}yahoo.fr)




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. De Troyer and T. A. Wilson
Effect of acute inflation on the mechanics of the inspiratory muscles
J Appl Physiol, July 1, 2009; 107(1): 315 - 323.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. De Troyer
Impact of diaphragmatic contraction on the stiffness of the canine mediastinum
J Appl Physiol, September 1, 2008; 105(3): 887 - 893.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. Leduc, M. Cappello, P. A. Gevenois, and A. De Troyer
Mechanics of the canine diaphragm in ascites: a CT study
J Appl Physiol, February 1, 2008; 104(2): 423 - 428.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. Leduc and A. De Troyer
Dysfunction of the canine respiratory muscle pump in ascites
J Appl Physiol, February 1, 2007; 102(2): 650 - 657.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. De Troyer and D. Leduc
Effects of single-lung inflation on inspiratory muscle function in dogs
J. Physiol., October 1, 2006; 576(1): 269 - 277.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. De Troyer and D. Leduc
Effect of diaphragmatic contraction on the action of the canine parasternal intercostals
J Appl Physiol, July 1, 2006; 101(1): 169 - 175.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. Leduc and A. D. Troyer
The effect of lung inflation on the inspiratory action of the canine parasternal intercostals
J Appl Physiol, March 1, 2006; 100(3): 858 - 863.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the American Physiological Society.