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Modeling the blood lactate kinetics at maximal short-term exercise conditions in children, adolescents, and adults

¹Centre for Sports and Exercise Science, Department of Biological Sciences, University of Essex, Colchester, United Kingdom; ²Department of Physical Medicine and Rehabilitation, Haukeland University Hospital, Bergen, Norway; and ³Institute of Sports Medicine, Free University, Berlin, Germany

Submitted 18 January 2005 ; accepted in final form 22 March 2005

Whether age-related differences in blood lactate concentrations (BLC) reflect specific BLC kinetics was analyzed in 15 prepubescent boys (age 12.0 ± 0.6 yr, height 1.54 ± 0.06 m, body mass 40.0 ± 5.2 kg), 12 adolescents (16.3 ± 0.7 yr, 1.83 ± 0.07 m, 68.2 ± 7.5 kg), and 12 adults (27.2 ± 4.5 yr, 1.83 ± 0.06 m, 81.6 ± 6.9 kg) by use of a biexponential four-parameter kinetics model under Wingate Anaerobic Test conditions. The model predicts the lactate generated in the extravasal compartment (A), invasion (k₁), and evasion (k₂) of lactate into and out of the blood compartment, the BLC maximum (BLC_max), and corresponding time (TBLC_max). BLC_max and TBLC_max were lower (P < 0.05) in boys (BLC_max 10.2 ± 1.3 mmol/l, TBLC_max 4.1 ± 0.4 min) than in adolescents (12.7 ± 1.0 mmol/l, 5.5 ± 0.7 min) and adults (13.7 ± 1.4 mmol/l, 5.7 ± 1.1 min). No differences were found in A related to the muscle mass (A_MM) and k₁ between boys (A_MM: 22.8 ± 2.7 mmol/l, k₁: 0.865 ± 0.115 min^–1), adolescents (22.7 ± 1.3 mmol/l, 0.692 ± 0.221 min^–1), and adults (24.7 ± 2.8 mmol/l, 0.687 ± 0.287 min^–1). The k₂ was higher (P < 0.01) in boys (2.87 10^–2 ± 0.75 10^–2 min^–1) than in adolescents (2.03 x 10^–2 ± 0.89 x 10^–2 min^–1) and adults (1.99 x 10^–2 ± 0.93 x 10^–2 min^–1). Age-related differences in the BLC kinetics are unlikely to reflect differences in muscular lactate or lactate invasion but partly faster elimination out of the blood compartment.

glycolysis; extravasal compartment; invasion; elimination

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