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Developmental changes in airway and tissue mechanics in mice

¹Division of Clinical Sciences, Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia; and ²Department of Medical Informatics and Engineering, University of Szeged, Szeged, Hungary

Submitted 4 October 2004 ; accepted in final form 14 March 2005

Most studies using mice to model human lung diseases are carried out in adults, although there is emerging interest in the effects of allergen, bacterial, and viral exposure early in life. This study aims to characterize lung function in BALB/c mice from infancy (2 wk) through to adulthood (8 wk). The low-frequency forced oscillation technique was used to obtain impedance data, partitioned into components representing airway resistance, tissue damping, tissue elastance, and hysteresivity (tissue damping/tissue elastance). Measurements were made at end-expiratory pause (transrespiratory system pressure = 2 cmH₂O) and during relaxed slow expiration from 20 to 0 cmH₂O. Airway resistance decreased with age from 0.63 cmH₂O·ml^–1·s at 2 wk to 0.24 cmH₂O·ml^–1·s at 8 wk (P < 0.001). Both tissue damping and tissue elastance decreased with age (P < 0.001) from 2 to 5 wk, then plateaued through to 8 wk (P < 0.001). This pattern was seen both in measurements taken at end-expiratory pause and during expiration. There were no age-related changes seen in hysteresivity when measured at end-expiratory pause, but the pattern of volume dependence did differ with the age of the mice. These changes in respiratory mechanics parallel the reported structural changes of the murine lung from the postnatal period into adulthood.

lung mechanics; mice; age; forced oscillations

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