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Decreased intestinal polyp multiplicity is related to exercise mode and gender in Apc^Min/+ mice

¹Division of Applied Physiology, Exercise Science Department, ²Department of Biological Sciences, and ³Center for Colon Cancer Research, University of South Carolina, Columbia, South Carolina

Submitted 7 September 2004 ; accepted in final form 4 February 2005

Moderate-intensity treadmill running can alter male Apc^Min/+ mouse polyp formation. This purpose of this study was to examine whether exercise mode differentially affects Apc^Min/+ mouse intestinal polyp development in male and female mice. Male and female Apc^Min/+ mice were randomly assigned to control, treadmill (18 m/min; 60 min/day; 6 days/wk), or voluntary wheel running (24-h access) groups. Nine weeks of training decreased total intestinal polyps by 29% in male treadmill runners (66 ± 9; P = 0.038) compared with male controls (93 ± 7). The number of large polyps (1-mm diameter) were also reduced by 38% in male treadmill runners (49 ± 6; P = 0.005) compared with male controls (79 ± 6). Treadmill running in female Apc^Min/+ mice and wheel running in both genders did not affect polyp number or size. Spleen weight decreased in male treadmill runners (91 ± 9 mg; P = 0.011) and wheel runners (75 ± 6 mg; P = 0.004) compared with controls (141 ± 13 mg). Plasma IL-6 was reduced by 96% in male treadmill runners (1.2 ± 0.6 pg/ml) and 78% in male wheel runners (6.6 ± 3.3 pg/ml) compared with control mice (27.9 ± 2.8 pg/ml; P < 0.05). Female mice responded similarly with an 86% decrease in plasma IL-6 with treadmill running (3.2 ± 1.2 pg/ml) and 90% decrease with wheel running (2.9 ± 2.0 pg/ml) compared with control mice (21.1 ± 5.3 pg/ml; P < 0.05). The crypt depth-to-villus height ratio in the intestine, an indirect marker of intestinal inflammation, decreased by 21 (P = 0.024) and 24% (P = 0.029), respectively, in male and female treadmill runners but not wheel runners. Physical activity-induced attenuation of intestinal polyp number and size is dependent on exercise mode and differs between genders. The modulation of systemic and intestinal inflammation may also depend on exercise mode.

colon cancer; treadmill running; activity wheel; interleukin-6; adenomatous polyposis coli

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