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An upper airway resonator model of high-frequency inspiratory sounds in children with sleep-disordered breathing

¹Cardiovascular Division, Departments of Internal Medicine and Physiology, and ²Sleep Disorders Center, Pulmonary and Critical Care Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia

Submitted 1 November 2004 ; accepted in final form 21 December 2004

The goal of this study was to determine how high-frequency inspiratory sounds (HFIS) are generated by sleeping children with obstructive sleep-disordered breathing (OSDB). We hypothesized that HFIS are generated when a high-velocity jet of air, generated by a narrowed upper airway, induces the upper airway to act as a resonating chamber. We tested two predictions of this hypothesis: 1) the upper airway is narrowed in children who make HFIS and 2) the length of the upper airway, calculated from HFIS harmonic intervals, is similar to that calculated from magnetic resonance imaging (MRI) scans. The study was conducted in the setting of a sleep laboratory. Participants included 29 children between 6 and 12 yr of age with adenotonsillar hypertrophy suspected of having OSDB. Minimum cross-sectional airway area and airway long dimensions (lips to larynx or soft palate) were measured in awake children with MRIs. Later that night, sound was recorded with a microphone suspended above their bed while the children underwent polysomnography. Sounds were later analyzed with fast Fourier transforms. We found that sleeping children who generated HFIS had significantly narrower upper airways compared with children who did not make HFIS [minimum airway area 20.5 ± 4.4 vs. 70.9 ± 22.5 mm² (mean ± SE), respectively; P = 0.02]. There was a significant inverse correlation between the log₁₀ of the narrowest airway area and the number of HFIS recorded per hour (r² = 0.55, P < 0.00001). The harmonics characteristics of HFIS predicted that they were generated by sound resonating in chamber whose length was 12.0 ± 0.9 cm, which is similar to the MRI measured distance from the lips to the larynx of 12.8 ± 0.4 cm. In conclusion, these data suggest that children generate HFIS when 1) they have a narrowed upper airway and 2) their upper airway acts as a resonating chamber.

sleep apnea; sleep apnea syndromes; snoring; sound; sound spectrography; respiratory sounds; fast fourier transform

This article has been cited by other articles:

				P. M. Suratt, M. Peruggia, L. D'Andrea, R. Diamond, J. T. Barth, M. Nikova, V. A. Perriello Jr, and M. L. Johnson Cognitive Function and Behavior of Children With Adenotonsillar Hypertrophy Suspected of Having Obstructive Sleep-Disordered Breathing Pediatrics, September 1, 2006; 118(3): e771 - e781. [Abstract] [Full Text] [PDF]

				R. F. Fregosi, S. F. Quan, C. Rembold, and P. Suratt MRI of pharyngeal airway in children with sleep-disordered breathing J Appl Physiol, December 1, 2005; 99(6): 2470 - 2470. [Full Text] [PDF]