Journal of Applied Physiology Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 98: 1547-1553, 2005; doi:10.1152/japplphysiol.01121.2004
8750-7587/05 $8.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (76)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Georges, P. C.
Right arrow Articles by Janmey, P. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Georges, P. C.
Right arrow Articles by Janmey, P. A.

INVITED REVIEW

HIGHLIGHTED TOPICS
Biomechanics and Mechanotransduction in Cells and Tissues

Cell type-specific response to growth on soft materials

Penelope C. Georges1,2 and Paul A. Janmey1,3

1Institute for Medicine and Engineering; and 2Departments of Bioengineering and 3Physiology and Physics, University of Pennsylvania, Philadelphia, Pennsylvania

Many cell types respond to forces as acutely as they do to chemical stimuli, but the mechanisms by which cells sense mechanical stimuli and how these factors alter cellular structure and function in vivo are far less explored than those triggered by chemical ligands. Forces arise both from effects outside the cell and from mechanochemical reactions within the cell that generate stresses on the surface to which the cells adhere. Several recent reviews have summarized how externally applied forces may trigger a cellular response (Silver FH and Siperko LM. Crit Rev Biomed Eng 31: 255–331, 2003; Estes BT, Gimble JM, and Guilak F. Curr Top Dev Biol 60: 91–126, 2004; Janmey PA and Weitz DA. Trends Biochem Sci 29: 364–370, 2004). The purpose of this review is to examine the information available in the current literature describing the relationship between a cell and the rigidity of the matrix on which it resides. We will review recent studies and techniques that focus on substrate compliance as a major variable in cell culture studies. We will discuss the specificity of cell response to stiffness and discuss how this may be important in particular tissue systems. We will attempt to link the mechanoresponse to real pathological states and speculate on the possible biological significance of mechanosensing.

mechanosensing; matrix compliance; extracellular matrix; mechanotransduction; polyacrylamide gel; matrigel


Address for reprint requests and other correspondence: P. A. Janmey, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA 19104 (E-mail: janmey{at}mail.med.upenn.edu)




This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
B. G. Coon, D. Mukherjee, C. B. Hanna, D. J. Riese II, M. Lowe, and R. C. Aguilar
Lowe syndrome patient fibroblasts display Ocrl1-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase
Hum. Mol. Genet., December 1, 2009; 18(23): 4478 - 4491.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. S. Chen
Mechanotransduction - a field pulling together?
J. Cell Sci., October 15, 2008; 121(20): 3285 - 3292.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
P. Patwari and R. T. Lee
Mechanical Control of Tissue Morphogenesis
Circ. Res., August 1, 2008; 103(3): 234 - 243.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
X. Zhou, R. G. Rowe, N. Hiraoka, J. P. George, D. Wirtz, D. F. Mosher, I. Virtanen, M. A. Chernousov, and S. J. Weiss
Fibronectin fibrillogenesis regulates three-dimensional neovessel formation
Genes & Dev., May 1, 2008; 22(9): 1231 - 1243.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
W.-T. Chiu, M.-J. Tang, H.-C. Jao, and M.-R. Shen
Soft Substrate Up-regulates the Interaction of STIM1 with Store-operated Ca2+ Channels That Lead to Normal Epithelial Cell Apoptosis
Mol. Biol. Cell, May 1, 2008; 19(5): 2220 - 2230.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
P. C. Georges, J.-J. Hui, Z. Gombos, M. E. McCormick, A. Y. Wang, M. Uemura, R. Mick, P. A. Janmey, E. E. Furth, and R. G. Wells
Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis
Am J Physiol Gastrointest Liver Physiol, December 1, 2007; 293(6): G1147 - G1154.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
D. E. Ingber
Cellular mechanotransduction: putting all the pieces together again
FASEB J, May 1, 2006; 20(7): 811 - 827.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
D. E. Discher, P. Janmey, and Y.-l. Wang
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Science, November 18, 2005; 310(5751): 1139 - 1143.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the American Physiological Society.