HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (28) Citing Articles via Google Scholar Google Scholar Articles by Fairey, A. S. Articles by Mackey, J. R. Search for Related Content PubMed PubMed Citation Articles by Fairey, A. S. Articles by Mackey, J. R.

TRANSLATIONAL PHYSIOLOGY

Randomized controlled trial of exercise and blood immune function in postmenopausal breast cancer survivors

Faculties of ¹Medicine, ²Physical Education, and ³Agricultural, Food, and Nutritional Sciences, University of Alberta, Edmonton, Canada

Submitted 2 June 2004 ; accepted in final form 19 November 2004

ABSTRACT

The objective was to determine the effects of exercise training on changes in blood immune function in postmenopausal breast cancer survivors. Fifty-three postmenopausal breast cancer survivors were randomly assigned to an exercise (n = 25) or control group (n = 28). The exercise group trained on cycle ergometers three times per week for 15 wk. The control group did not train. The primary end point was change in natural killer cell cytotoxic activity in isolated peripheral blood mononuclear cells. Secondary end points were changes in standard hematological variables, whole blood neutrophil function, the phenotypes of isolated mononuclear cells, estimations of unstimulated and phytohemaglutinin-stimulated mononuclear cell function (rate of [³H]thymidine uptake), and the production of proinflammatory [interleukin (IL)-1, tumor necrosis factor-, IL-6] and anti-inflammatory cytokines (IL-4, IL-10, transforming growth factor-₁). Statistical tests were two-sided ( < 0.05). Fifty-two participants completed the trial. Intention-to-treat analyses, which included the baseline value as a covariate, showed significant differences between groups for change in percent specific lysis of a target natural killer cell at all five effector-to-target ratios (adjusted mean between-group change over all 5 effector-to-target ratios = +6.34%; P < 0.05 for all comparisons), the lytic activity per cell (adjusted mean between-group change = –2.72 lytic units; P = 0.035), and unstimulated [³H]thymidine uptake by peripheral blood lymphocytes (adjusted mean between-group change = +218 per dpm x 10⁶ cells; P = 0.007). There were no significant differences between groups for change in any other end point. Exercise training increased natural killer cell cytotoxic activity and unstimulated [³H]thymidine uptake by peripheral blood lymphocytes in postmenopausal breast cancer survivors.

clinical exercise physiology; natural killer cell cytotoxic activity; unstimulated [³H]thymidine uptake

This article has been cited by other articles:

				C. L. Battaglini, A.C. Hackney, R. Garcia, D. Groff, E. Evans, and T. Shea The Effects of an Exercise Program in Leukemia Patients Integr Cancer Ther, June 1, 2009; 8(2): 130 - 138. [Abstract] [PDF]

				E. S. Evans, C. L. Battaglini, D. G. Groff, and A.C. Hackney Aerobic Exercise Intensity in Breast Cancer Patients: A Preliminary Investigation Integr Cancer Ther, June 1, 2009; 8(2): 139 - 147. [Abstract] [PDF]

				M. F. Leitzmann, C. Koebnick, C. C. Abnet, N. D. Freedman, Y. Park, A. Hollenbeck, R. Ballard-Barbash, and A. Schatzkin Prospective Study of Physical Activity and Lung Cancer by Histologic Type in Current, Former, and Never Smokers Am. J. Epidemiol., March 1, 2009; 169(5): 542 - 553. [Abstract] [Full Text] [PDF]

				B. Sternfeld, E. Weltzien, C. P. Quesenberry Jr., A. L. Castillo, M. Kwan, M. L. Slattery, and B. J. Caan Physical Activity and Risk of Recurrence and Mortality in Breast Cancer Survivors: Findings from the LACE Study Cancer Epidemiol. Biomarkers Prev., January 1, 2009; 18(1): 87 - 95. [Abstract] [Full Text] [PDF]

				P. T. Campbell, M. H. Wener, B. Sorensen, B. Wood, Z. Chen-Levy, J. D. Potter, A. McTiernan, and C. M. Ulrich Effect of exercise on in vitro immune function: a 12-month randomized, controlled trial among postmenopausal women J Appl Physiol, June 1, 2008; 104(6): 1648 - 1655. [Abstract] [Full Text] [PDF]

				K. S Courneya Physical Activity in Cancer Survivors: Possible Associations with Clinical Outcomes Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 417 - 420. [Abstract] [Full Text] [PDF]

				C. M. Schneider, C. C. Hsieh, L. K. Sprod, S. D. Carter, and R. Hayward Cancer treatment-induced alterations in muscular fitness and quality of life: the role of exercise training Ann. Onc., December 1, 2007; 18(12): 1957 - 1962. [Abstract] [Full Text] [PDF]

				C. Visovsky Muscle Strength, Body Composition, and Physical Activity in Women Receiving Chemotherapy for Breast Cancer Integr Cancer Ther, September 1, 2006; 5(3): 183 - 191. [Abstract] [PDF]