HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 98/4/1478    most recent 00910.2004v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Skorohod, N. Articles by Yeates, D. B. Search for Related Content PubMed PubMed Citation Articles by Skorohod, N. Articles by Yeates, D. B.

Superoxide dismutase failed to attenuate allergen-induced nasal congestion in ragweed-sensitized dogs

University of Illinois at Chicago, Chicago, Illinois

Submitted 20 August 2004 ; accepted in final form 15 December 2004

We hypothesized that augmentation of antioxidant defenses with exogenous superoxide dismutase (SOD), an enzyme that provides an initial defense against oxidative injury, would attenuate allergen-induced nasal congestion in the canine model of allergic rhinitis. Nasal congestion was evaluated by the measurements of nasal resistance and the volume of the nasal passage. In five nonsensitized dogs, 30,000 U of SOD from bovine erythrocytes delivered by aerosol to the nasal passages before histamine challenge reduced the histamine-induced nasal congestion. At 30 min postchallenge, nasal resistance was 1.14 ± 0.2 cmH₂O·l^–1·min^–1 in the saline pretreatment study vs. 0.36 ± 0.02 cmH₂O·l^–1·min^–1 in the SOD pretreatment study (P < 0.05), and volume of nasal passage was 10.9 ± 0.5 cm³ vs. 17.4 ± 1.3 cm³ (P < 0.05), respectively. In five sensitized dogs, however, neither an analogous pretreatment with SOD nor intranasal aerosolized pretreatment with 30,000 U of SOD conjugated to polyethylene glycol attenuated ragweed-induced nasal congestion. Also, systemic application of SOD did not attenuate responses to challenges with histamine and ragweed in nonsensitized and sensitized dogs, respectively. The antioxidant-induced attenuation of nasal congestion in nonsensitized dogs confirms validity of the model and indicates the involvement of free radical-mediated damage in the genesis of the histamine-induced congestion. In sensitized dogs, the data do not support the hypothesis that oxidative stress is a clinically significant component of acute ragweed-induced nasal congestion. The data do not support the use of SOD for acute protection against allergic rhinitis.

polyethylene glycol-superoxide dismutase; exogenous antioxidants; histamine; nasal resistance; nasal airway volume

This article has been cited by other articles:

				D. Wang, L. Qian, H. Xiong, J. Liu, W. S. Neckameyer, S. Oldham, K. Xia, J. Wang, R. Bodmer, and Z. Zhang From the Cover: Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila PNAS, September 5, 2006; 103(36): 13520 - 13525. [Abstract] [Full Text] [PDF]