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TRANSLATIONAL PHYSIOLOGY

Periodic acceleration: effects on vasoactive, fibrinolytic, and coagulation factors

¹Division of Neonatology and ²Department of Research, ³Department of Laboratory Medicine and Pathology, ⁵Division of Pulmonary Disease, Mount Sinai Medical Center; and ⁴Miami Heart Research Institute, Miami Beach, Florida

Submitted 25 June 2004 ; accepted in final form 18 October 2004

ABSTRACT

Cellular and isolated vessel experiments have shown that pulsatile and laminar shear stress to the endothelium produces significant release of mediators into the circulation. Periodic acceleration (pG_z) applied to the whole body in the direction of the spinal axis adds pulses to the circulation, thereby increasing pulsatile and shear stress to the endothelium that should also cause release of mediators into the circulation. The purpose of this study was to determine whether addition of pulses to the circulation through pG_z would be sufficient to increase shear stress in whole animals and to acutely release mediators and how such a physical maneuver might affect coagulation factors. Randomized control experiments were performed on anesthetized, supine piglets. The treatment group (pG_z) (n = 12) received pG_z with a motion platform that moved them repetitively head to foot at ±0.4 g at 180 cpm for 60 min. The control group (n = 6) was secured to the platform but remained on conventional ventilation throughout the 4-h protocol. Compared with control animals and baseline, pulsatile stress produced significant increases of serum nitrite, prostacyclin, PGE₂, and tissue plasminogen activator antigen and activity, as well as D-dimer. There were no significant changes in epinephrine, norepinephrine, cortisol, and coagulation factors between groups or from baseline values. Pulsatile and laminar shear stress to the endothelium induced by pG_z safely produces increases of vasoactive and fibrinolytic activity. pG_z has potential to achieve mediator-related benefits from the actions of nitric oxide and prostaglandins.

nitric oxide; prostaglandins; endothelin; pulsatile shear stress; endothelium

This article has been cited by other articles:

				A. Uryash, H. Wu, J. Bassuk, P. Kurlansky, M. A. Sackner, and J. A. Adams Low-amplitude pulses to the circulation through periodic acceleration induces endothelial-dependent vasodilatation J Appl Physiol, June 1, 2009; 106(6): 1840 - 1847. [Abstract] [Full Text] [PDF]

				W. M. Abraham, A. Ahmed, I. Serebriakov, I. T. Lauredo, J. Bassuk, J. A. Adams, and M. A. Sackner Whole-Body Periodic Acceleration Modifies Experimental Asthma in Sheep Am. J. Respir. Crit. Care Med., October 1, 2006; 174(7): 743 - 752. [Abstract] [Full Text] [PDF]

				M. A. Sackner, E. Gummels, and J. A. Adams Effect of Moderate-Intensity Exercise, Whole-Body Periodic Acceleration, and Passive Cycling on Nitric Oxide Release Into Circulation Chest, October 1, 2005; 128(4): 2794 - 2803. [Abstract] [Full Text] [PDF]