Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


J Appl Physiol 98: 477-481, 2005. First published September 24, 2004; doi:10.1152/japplphysiol.00130.2004
8750-7587/05 $8.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
98/2/477    most recent
00130.2004v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rosendal, L.
Right arrow Articles by Kristiansen, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rosendal, L.
Right arrow Articles by Kristiansen, J.

Increase in interstitial interleukin-6 of human skeletal muscle with repetitive low-force exercise

Lars Rosendal,1,2 Karen Søgaard,1 Michael Kjær,3 Gisela Sjøgaard,1 Henning Langberg,3 and Jesper Kristiansen1

1National Institute of Occupational Health, Copenhagen; 3Sports Medicine Research Unit and Copenhagen Muscle Research Centre, Bispebjerg Hospital, Copenhagen, Denmark; and 2Pain and Occupational Medicine Centre, University Hospital, Linköping, Sweden

Submitted 4 February 2004 ; accepted in final form 21 September 2004

Interleukin (IL)-6, which is released from muscle tissue during intense exercise, possesses important metabolic and probably anti-inflammatory properties. To evaluate the IL-6 response to low-intensity exercise, we conducted two studies: 1) a control study with insertion of microdialysis catheters in muscle and determination of interstitial muscle IL-6 response over 2 h of rest and 2) an exercise study to investigate the IL-6 response to 20 min of repetitive low-force exercise. In both studies, a microdialysis catheter (cutoff: 3,000 kDa) was inserted into the upper trapezius muscle of six male subjects, and the catheters were perfused with Ringer-acetate at 5 µl/min. Venous plasma samples were taken in the exercise study. The insertion of microdialysis catheters into muscle resulted in an increase in IL-6 from 8 ± 0 to 359 ± 171 and 484 ± 202 pg/ml after 65 and 110 min, respectively (P < 0.001). Similarly, in the exercise study, IL-6 increased to 289 ± 128 pg/ml after a 55-min rest (P < 0.001). During the subsequent repetitive low-force exercise, muscle IL-6 further increased to 1,246 ± 461 pg/ml and reached 2,132 ± 477 pg/ml after a 30-min recovery (all P < 0.001). In contrast to this, plasma IL-6 did not significantly change in response to exercise. We conclude that upper extremity, low-intensity exercise results in a substantial increase in IL-6 in the interstitium of the stabilizing trapezius muscle, whereas no change is seen for plasma IL-6.

metabolism; trauma; inflammation; cytokine; microdialysis



Address for reprint requests and other correspondence: L. Rosendal, National Institute of Occupational Health, Lersø Parkallé 105, DK-2100 Copenhagen, Denmark (E-mail: LRL{at}ami.dk)




This article has been cited by other articles:


Home page
J. Physiol.Home page
O. H. Mortensen, K. Andersen, C. Fischer, A. R. Nielsen, S. Nielsen, T. Akerstrom, M.-b. Aastrom, R. Borup, and B. K. Pedersen
Calprotectin is released from human skeletal muscle tissue during exercise
J. Physiol., July 15, 2008; 586(14): 3551 - 3562.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
X.-W. Yu, Q. Chen, R. H Kennedy, and S. J Liu
Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes
J. Physiol., July 15, 2005; 566(2): 327 - 340.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the American Physiological Society.