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J Appl Physiol 97: 2051-2055, 2004. First published August 20, 2004; doi:10.1152/japplphysiol.00626.2004
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Model of local temperature changes in brain upon functional activation

Christopher M. Collins,1 Michael B. Smith,1 and Robert Turner2

1Center for NMR Research, Department of Radiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033; and 2Wellcome Department of Cognitive Neurology, Institute of Neurology, University College London, WC1N 3BG London, United Kingdom

Submitted 18 June 2004 ; accepted in final form 17 August 2004

Experimental results for changes in brain temperature during functional activation show large variations. It is, therefore, desirable to develop a careful numerical model for such changes. Here, a three-dimensional model of temperature in the human head using the bioheat equation, which includes effects of metabolism, perfusion, and thermal conduction, is employed to examine potential temperature changes due to functional activation in brain. It is found that, depending on location in brain and corresponding baseline temperature relative to blood temperature, temperature may increase or decrease on activation and concomitant increases in perfusion and rate of metabolism. Changes in perfusion are generally seen to have a greater effect on temperature than are changes in metabolism, and hence active brain is predicted to approach blood temperature from its initial temperature. All calculated changes in temperature for reasonable physiological parameters have magnitudes <0.12°C and are well within the range reported in recent experimental studies involving human subjects.

perfusion; metabolism; heat; calculations


Address for reprint requests and other correspondence: C. M. Collins, Center for NMR Research, NMR/MRI Bldg., Dept. of Radiology H066, The Pennsylvania State Univ. College of Medicine, 500 Univ. Dr., Hershey, PA 17033 (E-mail: cmcollins{at}psu.edu)




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 Proc. Natl. Acad. Sci. USAHome page
A. L. Sukstanskii and D. A. Yablonskiy
Theoretical model of temperature regulation in the brain during changes in functional activity
PNAS, August 8, 2006; 103(32): 12144 - 12149.
[Abstract] [Full Text] [PDF]


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