HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (19) Citing Articles via Google Scholar Google Scholar Articles by Mitzner, W. Articles by Wagner, E. M. Search for Related Content PubMed PubMed Citation Articles by Mitzner, W. Articles by Wagner, E. M.

INVITED REVIEW

HIGHLIGHTED TOPICS
Lung Growth and Repair

Vascular remodeling in the circulations of the lung

Departments of Environmental Health Science and Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205

Submitted 4 May 2004 ; accepted in final form 19 May 2004

The lung is unique in its double sources of perfusion from the pulmonary and systemic circulations. One striking difference between the two circulations is the capacity for angiogenesis. The bronchial circulation has a capacity that seems quite similar to all systemic arteries, whereas the pulmonary circulation seems relatively inert in this regard. Extra-alveolar pulmonary arteries can grow somewhat in length, and septal capillaries seem to have the capability of reforming, but these processes do not seem to occur with nearly the same intensity associated with the bronchial arteries. In this review, we emphasize these differences between the two circulations of the lung, anticipating that future research will allow more focused probing into the molecular signaling that regulates the novel mechanistic and pathological pathways of each.

bronchial circulation; angiogenesis; pulmonary

This article has been cited by other articles:

				J. Aitsebaomo, A. L. Portbury, J. C. Schisler, and C. Patterson Brothers and Sisters: Molecular Insights Into Arterial-Venous Heterogeneity Circ. Res., October 24, 2008; 103(9): 929 - 939. [Abstract] [Full Text] [PDF]

				D. M. Shasby Cell-cell adhesion in lung endothelium Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L593 - L607. [Abstract] [Full Text] [PDF]

				W. C. Aird Phenotypic Heterogeneity of the Endothelium: II. Representative Vascular Beds Circ. Res., February 2, 2007; 100(2): 174 - 190. [Abstract] [Full Text] [PDF]

				K. Yamaji-Kegan, Q. Su, D. J. Angelini, H. C. Champion, and R. A. Johns Hypoxia-induced mitogenic factor has proangiogenic and proinflammatory effects in the lung via VEGF and VEGF receptor-2 Am J Physiol Lung Cell Mol Physiol, December 1, 2006; 291(6): L1159 - L1168. [Abstract] [Full Text] [PDF]

				N. J. Davie, E. V. Gerasimovskaya, S. E. Hofmeister, A. P. Richman, P. L. Jones, J. T. Reeves, and K. R. Stenmark Pulmonary Artery Adventitial Fibroblasts Cooperate with Vasa Vasorum Endothelial Cells to Regulate Vasa Vasorum Neovascularization: A Process Mediated by Hypoxia and Endothelin-1 Am. J. Pathol., June 1, 2006; 168(6): 1793 - 1807. [Abstract] [Full Text] [PDF]

				P. Herve, E. Fadel, P. Herve, and E. Fadel Systemic neovascularization of the lung after pulmonary artery occlusion: "decoding the Da Vinci code" J Appl Physiol, April 1, 2006; 100(4): 1101 - 1102. [Full Text] [PDF]

				M. E. De Paepe, Q. Mao, J. Powell, S. E. Rubin, P. DeKoninck, N. Appel, M. Dixon, and F. Gundogan Growth of Pulmonary Microvasculature in Ventilated Preterm Infants Am. J. Respir. Crit. Care Med., January 15, 2006; 173(2): 204 - 211. [Abstract] [Full Text] [PDF]

				G. Horvath and A. Wanner Inhaled corticosteroids: effects on the airway vasculature in bronchial asthma Eur. Respir. J., January 1, 2006; 27(1): 172 - 187. [Abstract] [Full Text] [PDF]

				K. R. Stenmark and I. F. McMurtry Vascular Remodeling Versus Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension: A Time for Reappraisal? Circ. Res., July 22, 2005; 97(2): 95 - 98. [Full Text] [PDF]