Journal of Applied Physiology
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J Appl Physiol 97: 1781-1786, 2004. First published July 9, 2004; doi:10.1152/japplphysiol.00814.2003
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Local heating of human skin causes hyperemia without mediation by muscarinic cholinergic receptors or prostanoids

Sandrine Golay,1 Christian Haeberli,2 Anne Delachaux,1 Lucas Liaudet,3 Paul Kucera,2 Bernard Waeber,1 and François Feihl1

1Division de Physiopathologie Clinique, and 3Soins Intensifs de Médecine, Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, and 2Institut de Physiologie, Université de Lausanne, CH-1005 Lausanne, Switzerland

Submitted 31 July 2003 ; accepted in final form 25 May 2004

Local changes in surface temperature have a powerful influence on the perfusion of human skin. Heating increases local skin blood flow, but the mechanisms and mediators of this response (thermal hyperemia response) are incompletely elucidated. In the present study, we examined the possible dependence of the thermal hyperemia response on stimulation of muscarinic cholinergic receptors and on production of vasodilator prostanoids. In 13 male healthy subjects aged 20–30 yr, a temperature-controlled chamber was positioned on the volar face of one forearm and used to raise surface temperature from 34 to 41°C. The time course of the resulting thermal hyperemia response was recorded with a laser-Doppler imager. In one experiment, each of eight subjects received an intravenous bolus of the antimuscarinic agent glycopyrrolate (4 µg/kg) on one visit and saline on the other. The thermal hyperemia response was determined within the hour after the injections. Glycopyrrolate effectively inhibited the skin vasodilation induced by iontophoresis of acetylcholine but did not influence the thermal hyperemia response. In a second experiment, conducted in five other subjects, 1 g of the cyclooxygenase inhibitor aspirin administered orally totally abolished the vasodilation induced in the skin by anodal current but also failed to modify the thermal hyperemia response. The present study excludes the stimulation of muscarinic receptors and the production of vasodilator prostaglandins as essential and nonredundant mechanisms for the vasodilation induced by local heating in human forearm skin.

regional blood flow; skin blood supply; skin temperature; laser-Doppler flowmetry; receptors; vasodilation; prostaglandins


Address for reprint requests and other correspondence: F. Feihl, Univ. Hospital, Div. of Pathophysiology, PPA MP 14, CH-1011 Lausanne, Switzerland. (E-mail: Francois.Feihl{at}chuv.hospvd.ch).




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