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J Appl Physiol 97: 1702-1708, 2004. First published June 25, 2004; doi:10.1152/japplphysiol.01272.2003
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Soluble gas exchange in the pulmonary airways of sheep

Carmel Schimmel,1 Susan L. Bernard,1 Joseph C. Anderson,1 Nayak L. Polissar,3 S. Lakshminarayan,1,4,* and Michael P. Hlastala1,2,*

1Department of Medicine; 2Department of Physiology and Biophysics, University of Washington, Seattle 98195-6522; 3Mountain Whisper Light Statistical Consulting, Seattle 98112-2913; and 4Veterans Affairs Medical Center, Seattle Washington 98108

Submitted 1 December 2003 ; accepted in final form 15 June 2004

We studied the airway gas exchange properties of five inert gases with different blood solubilities in the lungs of anesthetized sheep. Animals were ventilated through a bifurcated endobronchial tube to allow independent ventilation and collection of exhaled gases from each lung. An aortic pouch at the origin of the bronchial artery was created to control perfusion and enable infusion of a solution of inert gases into the bronchial circulation. Occlusion of the left pulmonary artery prevented pulmonary perfusion of that lung so that gas exchange occurred predominantly via the bronchial circulation. Excretion from the bronchial circulation (defined as the partial pressure of gas in exhaled gas divided by the partial pressure of gas in bronchial arterial blood) increased with increasing gas solubility (ranging from a mean of 4.2 x 10–5 for SF6 to 4.8 x 10–2 for ether) and increasing bronchial blood flow. Excretion was inversely affected by molecular weight (MW), demonstrating a dependence on diffusion. Excretions of the higher MW gases, halothane (MW = 194) and SF6 (MW = 146), were depressed relative to excretion of the lower MW gases ethane, cyclopropane, and ether (MW = 30, 42, 74, respectively). All results were consistent with previous studies of gas exchange in the isolated in situ trachea.

high-solubility gases; diffusion; bronchial circulation; aortic pouch


Address for reprint requests and other correspondence: M. P. Hlastala, Division of Pulmonary and Critical Care Medicine, Box 356522, Univ. of Washington, Seattle, WA 98195-6522 (E-mail: hlastala{at}u.washington.edu).




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J. C. Anderson, W. J. E. Lamm, and M. P. Hlastala
Measuring airway exchange of endogenous acetone using a single-exhalation breathing maneuver
J Appl Physiol, March 1, 2006; 100(3): 880 - 889.
[Abstract] [Full Text] [PDF]


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