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J Appl Physiol 97: 1603-1604, 2004; doi:10.1152/classicessays.00024.2004 Free Article
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EDITORIAL FOCUS

ESSAYS ON APS CLASSIC PAPERS

Understanding pulmonary gas exchange: ventilation-perfusion relationships

John B. West

Department of Medicine, University of California San Diego, La Jolla, California 92093-0623

ABSTRACT

This essay looks at the historical significance of four APS classic papers that are freely available online:

Fenn WO, Rahn H, and Otis AB. A theoretical study of the composition of the alveolar air at altitude. Am J Physiol 146: 637—653, 1946 (http://ajplegacy.physiology.org/cgi/reprint/146/5/637).

Rahn H. A concept of mean alveolar air and the ventilation-bloodflow relationships during pulmonary gas exchange. Am J Physiol 158: 21—30, 1949 (http://ajplegacy.physiology.org/cgi/reprint/158/1/21).

Riley RL and Cournand A. "Ideal" alveolar air and the analysis of ventilation-perfusion relationships in the lungs. J Appl Physiol 1: 825—847, 1949 (http://jap.physiology.org/cgi/reprint/1/12/825).

Riley RL and Cournand A. Analysis of factors affecting partial pressures of oxygen and carbon dioxide in gas and blood of lungs: theory. J Appl Physiol 4: 77—101, 1951 (http://jap.physiology.org/cgi/reprint/4/2/77).



Address for correspondence: J. B. West, UCSD Dept. of Medicine 0623A, 9500 Gilman Drive, La Jolla, CA 92093-0623 (E-mail: jwest{at}ucsd.edu).




This article has been cited by other articles:


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D. Curran-Everett
A classic learning opportunity from Fenn, Rahn, and Otis (1946): the alveolar gas equation
Advan Physiol Educ, June 1, 2006; 30(2): 58 - 62.
[Abstract] [Full Text] [PDF]




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